N-(4-methoxybenzyl)-2-methyl-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

Base Information

Chemical Name:N-(4-methoxybenzyl)-2-methyl-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide
CAS No.:1450923-62-2
Molecular Formula:C₂₀H₂₁N₃O₄S₂
Molecular Weight:431.536
Hs Code.:

Synonyms:N-(4-methoxybenzyl)-2-methyl-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

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Chemical Property of N-(4-methoxybenzyl)-2-methyl-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

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Technology Process of N-(4-methoxybenzyl)-2-methyl-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

There total 6 articles about N-(4-methoxybenzyl)-2-methyl-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1450923-61-1
N-(4-methoxybenzyl)-2-methyl-3-oxo-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

: 1450923-62-2
N-(4-methoxybenzyl)-2-methyl-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

Guidance literature:: With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 25 ℃; for 5h;

Reference yield:

: 2369-13-3
3-fluoro-4-nitroaniline

: 1450923-62-2
N-(4-methoxybenzyl)-2-methyl-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C

1.2: 1 h / 25 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 - 25 °C

2.2: 1 h / -78 - 25 °C

3.1: sodium trimethylsilanolate / tetrahydrofuran / 2 h / 0 - 25 °C

4.1: acetic acid; iron / 2 h / 70 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 3.5 h / 0 - 60 °C

6.1: dimethylsulfide borane complex / tetrahydrofuran / 5 h / 0 - 25 °C

With hydrogenchloride; dimethylsulfide borane complex; sodium trimethylsilanolate; iron; potassium carbonate; acetic acid; lithium hexamethyldisilazane; sodium nitrite; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 1450923-59-7
3-hydroxy-N-(4-methoxybenzyl)-4-nitro-N-(thiazol-2-yl)benzenesulfonamide

: 1450923-62-2
N-(4-methoxybenzyl)-2-methyl-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; iron / 2 h / 70 °C

2: potassium carbonate / N,N-dimethyl-formamide / 3.5 h / 0 - 60 °C

3: dimethylsulfide borane complex / tetrahydrofuran / 5 h / 0 - 25 °C

With dimethylsulfide borane complex; iron; potassium carbonate; acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;