3-fluoro-N-(4-methoxybenzyl)-4-nitro-N-(thiazol-2-yl)benzenesulfonamide

Base Information

Chemical Name:3-fluoro-N-(4-methoxybenzyl)-4-nitro-N-(thiazol-2-yl)benzenesulfonamide
CAS No.:1450923-58-6
Molecular Formula:C₁₇H₁₄FN₃O₅S₂
Molecular Weight:423.446
Hs Code.:

Synonyms:3-fluoro-N-(4-methoxybenzyl)-4-nitro-N-(thiazol-2-yl)benzenesulfonamide

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Chemical Property of 3-fluoro-N-(4-methoxybenzyl)-4-nitro-N-(thiazol-2-yl)benzenesulfonamide

Chemical Property:

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Technology Process of 3-fluoro-N-(4-methoxybenzyl)-4-nitro-N-(thiazol-2-yl)benzenesulfonamide

There total 3 articles about 3-fluoro-N-(4-methoxybenzyl)-4-nitro-N-(thiazol-2-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 384858-14-4
N-[(4-methoxyphenyl)methyl]thiazole 2-amine

: 86156-93-6
3-fluoro-4-nitrobenzene-1-sulfonyl chloride

: 1450923-58-6
3-fluoro-N-(4-methoxybenzyl)-4-nitro-N-(thiazol-2-yl)benzenesulfonamide

Guidance literature:: N-[(4-methoxyphenyl)methyl]thiazole 2-amine; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 0 ℃; for 0.166667h;

3-fluoro-4-nitrobenzene-1-sulfonyl chloride; In tetrahydrofuran; at -78 ℃; for 0.25h;
DOI:10.1016/j.bmcl.2017.05.070

Reference yield:

: 2369-13-3
3-fluoro-4-nitroaniline

: 1450923-58-6
3-fluoro-N-(4-methoxybenzyl)-4-nitro-N-(thiazol-2-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C

1.2: 1 h / 25 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 - 25 °C

2.2: 1 h / -78 - 25 °C

With hydrogenchloride; lithium hexamethyldisilazane; sodium nitrite; In tetrahydrofuran; water;

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 1450923-58-6
3-fluoro-N-(4-methoxybenzyl)-4-nitro-N-(thiazol-2-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triisopropoxytitanium(IV) chloride / dichloromethane / 0.5 h / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -78 - 0 °C

2.2: 0.25 h / -78 °C

With triisopropoxytitanium(IV) chloride; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2017.05.070