N-(3-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)-2-(methylsulfonyl)guanidino)methyl)phenyl)-3-phenylpropiolamide

Base Information

Chemical Name:N-(3-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)-2-(methylsulfonyl)guanidino)methyl)phenyl)-3-phenylpropiolamide
CAS No.:1431958-67-6
Molecular Formula:C₂₆H₂₄N₆O₃S
Molecular Weight:500.581
Hs Code.:

Synonyms:N-(3-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)-2-(methylsulfonyl)guanidino)methyl)phenyl)-3-phenylpropiolamide

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Chemical Property of N-(3-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)-2-(methylsulfonyl)guanidino)methyl)phenyl)-3-phenylpropiolamide

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Technology Process of N-(3-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)-2-(methylsulfonyl)guanidino)methyl)phenyl)-3-phenylpropiolamide

There total 3 articles about N-(3-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)-2-(methylsulfonyl)guanidino)methyl)phenyl)-3-phenylpropiolamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1431960-26-7
C₁₇H₂₀N₆O₂S

: 637-44-5
phenylpropyolic acid

: 1431958-67-6
N-(3-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)-2-(methylsulfonyl)guanidino)methyl)phenyl)-3-phenylpropiolamide

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 888498-07-5
(1H-pyrrolo[2,3-b]pyridin-4-yl)methanamine

: 1431958-67-6
N-(3-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)-2-(methylsulfonyl)guanidino)methyl)phenyl)-3-phenylpropiolamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 3 h

2: isopropyl alcohol / 1 h / 160 °C / Microwave irradiation

3: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / N,N-dimethyl-formamide; ethyl acetate

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1431960-25-6
C₁₆H₁₆N₄O₃S

: 1431958-67-6
N-(3-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)-2-(methylsulfonyl)guanidino)methyl)phenyl)-3-phenylpropiolamide

Guidance literature:: Multi-step reaction with 2 steps

1: isopropyl alcohol / 1 h / 160 °C / Microwave irradiation

2: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / N,N-dimethyl-formamide; ethyl acetate

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;