(1S,6R)-1-cyano-3,4-dimethyl-6-phenyl-3-cyclohexen-1-carboxylate of (S)-ethyl lactate

Base Information

Chemical Name:(1S,6R)-1-cyano-3,4-dimethyl-6-phenyl-3-cyclohexen-1-carboxylate of (S)-ethyl lactate
CAS No.:144901-85-9
Molecular Formula:C₂₁H₂₅NO₄
Molecular Weight:355.434
Hs Code.:

Synonyms:(1S,6R)-1-cyano-3,4-dimethyl-6-phenyl-3-cyclohexen-1-carboxylate of (S)-ethyl lactate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,6R)-1-cyano-3,4-dimethyl-6-phenyl-3-cyclohexen-1-carboxylate of (S)-ethyl lactate

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Technology Process of (1S,6R)-1-cyano-3,4-dimethyl-6-phenyl-3-cyclohexen-1-carboxylate of (S)-ethyl lactate

There total 4 articles about (1S,6R)-1-cyano-3,4-dimethyl-6-phenyl-3-cyclohexen-1-carboxylate of (S)-ethyl lactate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 133382-26-0
(E)-2-cyanocinnamate of (S)-ethyl lactate

: 513-81-5
2,3-dimethyl-buta-1,3-diene

: 144901-85-9
(1S,6R)-1-cyano-3,4-dimethyl-6-phenyl-3-cyclohexen-1-carboxylate of (S)-ethyl lactate

Guidance literature:: With titanium tetrachloride; In dichloromethane; at -25 ℃; for 5h;
DOI:10.1016/S0957-4166(00)82189-8

Reference yield:

: 687-47-8
(S)-Ethyl lactate

: 144901-85-9
(1S,6R)-1-cyano-3,4-dimethyl-6-phenyl-3-cyclohexen-1-carboxylate of (S)-ethyl lactate

Guidance literature:: Multi-step reaction with 2 steps

1: 91.5 percent / N,N-dimethyl-4-aminopyridine, N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / a) 0 deg C, 1 h, 2.) RT, 20 h

2: 89 percent / TiCl₄ / CH₂Cl₂ / 5 h / -25 °C

With dmap; titanium tetrachloride; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1016/S0957-4166(00)82189-8

Reference yield:

: 14378-06-4
(E)-α-cyanocinnamic acid

: 144901-85-9
(1S,6R)-1-cyano-3,4-dimethyl-6-phenyl-3-cyclohexen-1-carboxylate of (S)-ethyl lactate

Guidance literature:: Multi-step reaction with 2 steps

1: 91.5 percent / N,N-dimethyl-4-aminopyridine, N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / a) 0 deg C, 1 h, 2.) RT, 20 h

2: 89 percent / TiCl₄ / CH₂Cl₂ / 5 h / -25 °C

With dmap; titanium tetrachloride; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1016/S0957-4166(00)82189-8