trans 1-(2'-methoxy-5'-methylphenyl)-1,2,3,4-tetrahydro-2-naphthaleneacetic acid

Base Information

• Chemical Name: trans 1-(2'-methoxy-5'-methylphenyl)-1,2,3,4-tetrahydro-2-naphthaleneacetic acid
• CAS No.: 135107-78-7
• Molecular Formula: C₂₀H₂₂O₃
• Molecular Weight: 310.393

Synonyms:trans 1-(2'-methoxy-5'-methylphenyl)-1,2,3,4-tetrahydro-2-naphthaleneacetic acid

Chemical Property of trans 1-(2'-methoxy-5'-methylphenyl)-1,2,3,4-tetrahydro-2-naphthaleneacetic acid

Chemical Property:

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Technology Process of trans 1-(2'-methoxy-5'-methylphenyl)-1,2,3,4-tetrahydro-2-naphthaleneacetic acid

There total 6 articles about trans 1-(2'-methoxy-5'-methylphenyl)-1,2,3,4-tetrahydro-2-naphthaleneacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-hydroxy-1-(2'-methoxy-5'-methylphenyl)-1,2,3,4-tetrahydro-2-naphthaleneacetic acid lactone (135107-76-5) → trans 1-(2'-methoxy-5'-methylphenyl)-1,2,3,4-tetrahydro-2-naphthaleneacetic acid (135107-78-7) + cis 1-(2'-methoxy-5'-methylphenyl)-1,2,3,4-tetrahydro-2-naphthaleneacetic acid (135107-77-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; at 65 - 68 ℃; for 5h; Yield given. Yields of byproduct given;

DOI:10.1021/jo00018a030

Reference yield:

1,2,3,4-tetrahydro-1-oxo-2-naphthaleneacetic acid (6742-31-0) → trans 1-(2'-methoxy-5'-methylphenyl)-1,2,3,4-tetrahydro-2-naphthaleneacetic acid (135107-78-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 79 percent / conc. H₂SO₄ / benzene / 24 h / Heating

3: H₂ / 10percent Pd-C / acetic acid / 5 h / 65 - 68 °C

With sulfuric acid; hydrogen; palladium on activated charcoal; In acetic acid; benzene;

DOI:10.1021/jo00018a030

Reference yield:

2-bromo-p-cresol (6627-55-0) → trans 1-(2'-methoxy-5'-methylphenyl)-1,2,3,4-tetrahydro-2-naphthaleneacetic acid (135107-78-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 79 percent / NaOH / H₂O / 2 h / Heating

3: H₂ / 10percent Pd-C / acetic acid / 5 h / 65 - 68 °C

With sodium hydroxide; hydrogen; palladium on activated charcoal; In water; acetic acid;

DOI:10.1021/jo00018a030

upstream raw materials:

1-hydroxy-1-(2'-methoxy-5'-methylphenyl)-1,2,3,4-tetrahydro-2-naphthaleneacetic acid lactone

2-bromo-p-cresol

2-bromo-4-methylanisole

1,2,3,4-tetrahydro-1-oxo-2-naphthaleneacetic acid methyl ester

Downstream raw materials:

trans 1-(2'-methoxy-5'-methylphenyl)-1,2,3,4-tetrahydro-2-naphthaleneacetic acid methyl ester

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