3-[3-(2,2-Bis-methoxycarbonyl-acetyl)-2-bromo-phenyl]-2-methoxycarbonyl-3-oxo-propionic acid methyl ester

Base Information

• Chemical Name: 3-[3-(2,2-Bis-methoxycarbonyl-acetyl)-2-bromo-phenyl]-2-methoxycarbonyl-3-oxo-propionic acid methyl ester
• CAS No.: 1026263-75-1
• Molecular Formula: C₁₈H₁₇BrO₁₀
• Molecular Weight: 473.231
• Mol file: 1026263-75-1.mol

Synonyms:3-[3-(2,2-Bis-methoxycarbonyl-acetyl)-2-bromo-phenyl]-2-methoxycarbonyl-3-oxo-propionic acid methyl ester

Chemical Property of 3-[3-(2,2-Bis-methoxycarbonyl-acetyl)-2-bromo-phenyl]-2-methoxycarbonyl-3-oxo-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[3-(2,2-Bis-methoxycarbonyl-acetyl)-2-bromo-phenyl]-2-methoxycarbonyl-3-oxo-propionic acid methyl ester

There total 2 articles about 3-[3-(2,2-Bis-methoxycarbonyl-acetyl)-2-bromo-phenyl]-2-methoxycarbonyl-3-oxo-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromoisophthalic acid (22433-91-6) → 3-[3-(2,2-Bis-methoxycarbonyl-acetyl)-2-bromo-phenyl]-2-methoxycarbonyl-3-oxo-propionic acid methyl ester (1026263-75-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 27.9 g / SOCl₂ / Heating

2: NaH / paraffin; tetrahydrofuran / 15 h / Heating

With thionyl chloride; sodium hydride; In tetrahydrofuran; paraffin;

DOI:10.1021/jo951919h

Reference yield:

2-bromobenzene-1,3-dicarboxylic acid dichloride (151603-30-4) + malonic acid dimethyl ester (108-59-8) → 3-[3-(2,2-Bis-methoxycarbonyl-acetyl)-2-bromo-phenyl]-2-methoxycarbonyl-3-oxo-propionic acid methyl ester (1026263-75-1)

Guidance literature:

With sodium hydride; In tetrahydrofuran; paraffin; for 15h; Heating;

DOI:10.1021/jo951919h

Reference yield: 75.0%

3-[3-(2,2-Bis-methoxycarbonyl-acetyl)-2-bromo-phenyl]-2-methoxycarbonyl-3-oxo-propionic acid methyl ester (1026263-75-1) → 2-bromo-1,3-diacetylbenzene (174833-49-9)

Guidance literature:

With sulfuric acid; acetic acid; In water; for 24h; Heating;

DOI:10.1021/jo951919h

upstream raw materials:

2-bromobenzene-1,3-dicarboxylic acid dichloride

malonic acid dimethyl ester

2-bromoisophthalic acid

Downstream raw materials:

2-bromo-1,3-diacetylbenzene

2,6-bis(1-(R)-ethoxyethyl)bromobenzene

bis<2,6-bis(1-(R)-ethoxyethyl)phenyl> diselenide

(S)-1-[2-Bromo-3-((S)-1-hydroxy-ethyl)-phenyl]-ethanol