carbobenzoxy-D-valyl-L-prolylsarcosine methyl ester

Base Information

• Chemical Name: carbobenzoxy-D-valyl-L-prolylsarcosine methyl ester
• CAS No.: 79663-88-0
• Molecular Formula: C₂₂H₃₁N₃O₆
• Molecular Weight: 433.505
• Mol file: 79663-88-0.mol

Synonyms:carbobenzoxy-D-valyl-L-prolylsarcosine methyl ester

Chemical Property of carbobenzoxy-D-valyl-L-prolylsarcosine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of carbobenzoxy-D-valyl-L-prolylsarcosine methyl ester

There total 5 articles about carbobenzoxy-D-valyl-L-prolylsarcosine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-proline methyl ester (2577-48-2) → carbobenzoxy-D-valyl-L-prolylsarcosine methyl ester (79663-88-0)

Guidance literature:

Multi-step reaction with 4 steps

1: dicyclohexylcarbodiimide / CHCl₃ / 20 h / Ambient temperature

2: 19.15 g / 1 N NaOH / ethanol / 20 h / Ambient temperature

3: Et₃N / acetonitrile / 0.25 h / -5 °C

4: 8.41 g / Et₃N / acetonitrile / -5 deg C, 1 h; RT, 20 h

With sodium hydroxide; triethylamine; dicyclohexyl-carbodiimide; In ethanol; chloroform; acetonitrile;

DOI:10.1021/ja00365a032

Reference yield:

carbobenzoxy-D-valine (1685-33-2) → carbobenzoxy-D-valyl-L-prolylsarcosine methyl ester (79663-88-0)

Guidance literature:

Multi-step reaction with 4 steps

1: dicyclohexylcarbodiimide / CHCl₃ / 20 h / Ambient temperature

2: 19.15 g / 1 N NaOH / ethanol / 20 h / Ambient temperature

3: Et₃N / acetonitrile / 0.25 h / -5 °C

4: 8.41 g / Et₃N / acetonitrile / -5 deg C, 1 h; RT, 20 h

With sodium hydroxide; triethylamine; dicyclohexyl-carbodiimide; In ethanol; chloroform; acetonitrile;

DOI:10.1021/ja00365a032

Reference yield:

carbobenzoxy-D-valyl-L-proline methyl ester (51782-77-5) → carbobenzoxy-D-valyl-L-prolylsarcosine methyl ester (79663-88-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 19.15 g / 1 N NaOH / ethanol / 20 h / Ambient temperature

2: Et₃N / acetonitrile / 0.25 h / -5 °C

3: 8.41 g / Et₃N / acetonitrile / -5 deg C, 1 h; RT, 20 h

With sodium hydroxide; triethylamine; In ethanol; acetonitrile;

DOI:10.1021/ja00365a032

upstream raw materials:

N-methylglycine methyl ester hydrochloride

L-proline methyl ester

carbobenzoxy-D-valine

carbobenzoxy-D-valyl-L-proline methyl ester

Downstream raw materials:

O-benzyl-L-threonyl-D-valyl-L-prolylsarcosine methyl ester

cyclo-(O-benzyl-L-threonyl-D-valyl-L-prolylsarcosyl-N-methyl-L-alanyl)

N-tert-butoxycarbonyl-O-benzyl-L-threonyl-D-valyl-L-prolylsarcosine methyl ester

N-tert-butoxycarbonyl-N-methyl-L-alanyl-O-benzyl-L-threonyl-D-valyl-L-prolylsarcosine