4R-{2S-[2-(3S-hydroxy-7-tritylsulfanylhept-4E-enoylamino)propionylamino]-3-tritylsulfanylpropionylamino}-5R-methyl-3S-triisopropylsilanyloxyhexanoic acid 2,2,2-trichloroethyl ester

Base Information

Chemical Name:4R-{2S-[2-(3S-hydroxy-7-tritylsulfanylhept-4E-enoylamino)propionylamino]-3-tritylsulfanylpropionylamino}-5R-methyl-3S-triisopropylsilanyloxyhexanoic acid 2,2,2-trichloroethyl ester
CAS No.:663919-03-7
Molecular Formula:C₆₉H₈₄Cl₃N₃O₇S₂Si
Molecular Weight:1266.02
Hs Code.:

4R-{2S-[2-(3S-hydroxy-7-tritylsulfanylhept-4E-enoylamino)propionylamino]-3-tritylsulfanylpropionylamino}-5R-methyl-3S-triisopropylsilanyloxyhexanoic acid 2,2,2-trichloroethyl ester

Synonyms:4R-{2S-[2-(3S-hydroxy-7-tritylsulfanylhept-4E-enoylamino)propionylamino]-3-tritylsulfanylpropionylamino}-5R-methyl-3S-triisopropylsilanyloxyhexanoic acid 2,2,2-trichloroethyl ester

Suppliers and Price of 4R-{2S-[2-(3S-hydroxy-7-tritylsulfanylhept-4E-enoylamino)propionylamino]-3-tritylsulfanylpropionylamino}-5R-methyl-3S-triisopropylsilanyloxyhexanoic acid 2,2,2-trichloroethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4R-{2S-[2-(3S-hydroxy-7-tritylsulfanylhept-4E-enoylamino)propionylamino]-3-tritylsulfanylpropionylamino}-5R-methyl-3S-triisopropylsilanyloxyhexanoic acid 2,2,2-trichloroethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4R-{2S-[2-(3S-hydroxy-7-tritylsulfanylhept-4E-enoylamino)propionylamino]-3-tritylsulfanylpropionylamino}-5R-methyl-3S-triisopropylsilanyloxyhexanoic acid 2,2,2-trichloroethyl ester

There total 12 articles about 4R-{2S-[2-(3S-hydroxy-7-tritylsulfanylhept-4E-enoylamino)propionylamino]-3-tritylsulfanylpropionylamino}-5R-methyl-3S-triisopropylsilanyloxyhexanoic acid 2,2,2-trichloroethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 663918-95-4
(3S,4E)-3-hydroxy-1-((4R)-4-isopropyl-2-thioxothiazolidin-3-yl)-7-tritylsulfanyl-hept-4-en-1-one

: (3S,4R)-4-[(S)-2-((R)-2-Amino-propionylamino)-3-tritylsulfanyl-propionylamino]-5-methyl-3-triisopropylsilanyloxy-hexanoic acid 2,2,2-trichloro-ethyl ester

: 663919-03-7
4R-{2S-[2-(3S-hydroxy-7-tritylsulfanylhept-4E-enoylamino)propionylamino]-3-tritylsulfanylpropionylamino}-5R-methyl-3S-triisopropylsilanyloxyhexanoic acid 2,2,2-trichloroethyl ester

Guidance literature:: With dmap; In dichloromethane; at 20 ℃; for 7h;
DOI:10.1021/ja039258q

Reference yield:

: 180973-22-2
(2E)-5-[(triphenylmethyl)thio]-2-pentenal

: 663919-03-7
4R-{2S-[2-(3S-hydroxy-7-tritylsulfanylhept-4E-enoylamino)propionylamino]-3-tritylsulfanylpropionylamino}-5R-methyl-3S-triisopropylsilanyloxyhexanoic acid 2,2,2-trichloroethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: TiCl₄; DIEA / CH₂Cl₂ / 2 h / -78 °C

1.2: 76 percent / CH₂Cl₂ / 0.5 h / -78 °C

2.1: 176 mg / DMAP / CH₂Cl₂ / 7 h / 20 °C

With dmap; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/ja039258q

Reference yield:

: 182360-34-5
D-N-(tert-butoxycarbonyl)valine pentafluorophenyl ester

: 663919-03-7
4R-{2S-[2-(3S-hydroxy-7-tritylsulfanylhept-4E-enoylamino)propionylamino]-3-tritylsulfanylpropionylamino}-5R-methyl-3S-triisopropylsilanyloxyhexanoic acid 2,2,2-trichloroethyl ester

Guidance literature:: Multi-step reaction with 11 steps

1.1: LDA / tetrahydrofuran / 1 h / -78 °C

1.2: 2.38 g / tetrahydrofuran / 0.75 h / -78 °C

2.1: 70 percent / potassium borohydride / methanol / 0.83 h / -78 - 0 °C

3.1: aq. LiOH / tetrahydrofuran / 2 h / 20 °C

4.1: 569 g / DCC; DMAP / CH₂Cl₂ / 18 h / 20 °C

5.1: TFA / CH₂Cl₂ / 3 h / 0 °C

6.1: 808.5 mg / PyBOP; DIEA / 0.33 h / 20 °C

7.1: 93 percent / 2,6-lutidine / CH₂Cl₂ / 4.5 h / 0 - 20 °C

8.1: EtNH₂ / acetonitrile / 3 h / 20 °C

9.1: 174.1 mg / PyBOP; DIEA / CH₂Cl₂ / 2 h / 20 °C

10.1: EtNH₂ / acetonitrile / 5 h / 20 °C

11.1: 176 mg / DMAP / CH₂Cl₂ / 7 h / 20 °C

With 2,6-dimethylpyridine; dmap; lithium hydroxide; potassium borohydride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile; 1.2: Claisen condensation;
DOI:10.1021/ja039258q