182360-34-5

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 640-68-6 D-Val-OH 
• 771-61-9 2,3,4,5,6-pentafluorophenol 
• 22838-58-0 Boc-D-Val-OH 

Downstream Products

• 876954-01-7 (S)-1-((S)-2-{(S)-2-[(3S,4R)-4-tert-Butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-5-methyl-hexanoyloxy]-3-methyl-butyrylamino}-4-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid benzyl ester 
• 766513-99-9 1-{2-[2-(4-{3-[2-(benzyloxycarbonyl-methyl-amino)-3-naphthalen-2-yl-propionyloxy]-2-tert-butoxycarbonylamino-butyrylamino}-3-hydroxy-5-methyl-hexanoyloxy)-3-methyl-butyrylamino]-4-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid benzyl ester 
• 766513-82-0 C₅₇H₇₉N₅O₁₅ 
• 766513-83-1 C₄₂H₆₇N₅O₁₃ 
• 945473-52-9 C₄₂H₆₅N₅O₁₂ 
• 766513-86-4 C₃₉H₆₇N₃O₉Si 
• 766513-88-6 C₅₆H₇₉N₅O₁₅ 
• 947139-80-2 C₄₁H₆₇N₅O₁₃ 
• 766513-89-7 C₄₁H₆₅N₅O₁₂ 
• 1242430-49-4 N-Boc-D-Val-(S)-5-benzyl-4-methoxy-3-methyl-1H-pyrrol-2(5H)-one 
• 182360-30-1 2(R)-(1',1'-dimethylallylamino)-3-methylbutyric acid 2,3,4,5,6-pentafluorophenyl ester 
• 663919-07-1 epi-4R-{2S-[2-(3R-hydroxy-7-tritylsulfanylhept-4E-enoylamino)propionylamino]-3-tritylsulfanylpropionylamino}-5R-methyl-3S-triisopropylsilanyloxyhexanoic acid 2,2,2-trichloroethyl ester 
• 663919-03-7 4R-{2S-[2-(3S-hydroxy-7-tritylsulfanylhept-4E-enoylamino)propionylamino]-3-tritylsulfanylpropionylamino}-5R-methyl-3S-triisopropylsilanyloxyhexanoic acid 2,2,2-trichloroethyl ester 
• 663919-08-2 epi-4R-{2S-[2-(3R-hydroxy-7-tritylsulfanylhept-4E-enoylamino)propionylamino]-3-tritylsulfanylpropionylamino}-5R-methyl-3S-triisopropylsilanyloxyhexanoic acid 

Relevant academic research and scientific papers

The first enantioselective synthesis of cytotoxic marine natural product palau'imide and assignment of its C-20 stereochemistry

Methyl tetramate derivative 6 has been developed as a new building block for the flexible and racemization-free synthesis of methyl 5-benzyl-3- methyltetramate via alkylation, and used in the first asymmetric synthesis of palau'imide (1). This allowed the establishment of the hitherto unknown stereochemistry at the C-20 of palau'imide as S.

Synthesis and biological evaluation of tamandarin B analogues

The synthesis of two tamandarin B analogues in which the N,O-Me 2Tyr5 unit was replaced by N-Me-phenylalanine (N-MePhe5) and (S)-2-(methylamino)-3-(naphthalen-2-yl)propanoic acid (N-MeNaphth5) is described. The

Total Synthesis of Spiruchostatin A, a Potent Histone Deacetylase Inhibitor

The total synthesis of spiruchostatin A was accomplished, unambiguously confirming its structure. Key steps included the use of the Nagao thiazolidinethione auxiliary for a diastereoselective acetate aldol reaction and as an activated acylating agent for amide formation, and macrolactonization by the Yamaguchi protocol. Spiruchostatin A is shown to have biological activity similar to that of FK228, a potent histone deacetylase (HDAC) inhibitor in clinical trials. The spiruchostatin A analogue, epimeric at the β-hydroxy acid, is inactive, highlighting the importance of stereochemistry at this position for interactions with HDACs. Copyright