(Z)-10-(1-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)vinyl)-2,4,6-trimethoxyphenanthrene

Base Information

• Chemical Name: (Z)-10-(1-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)vinyl)-2,4,6-trimethoxyphenanthrene
• CAS No.: 1400655-58-4
• Molecular Formula: C₃₄H₃₂O₆
• Molecular Weight: 536.624
• Mol file: 1400655-58-4.mol

Synonyms:(Z)-10-(1-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)vinyl)-2,4,6-trimethoxyphenanthrene

Chemical Property of (Z)-10-(1-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)vinyl)-2,4,6-trimethoxyphenanthrene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-10-(1-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)vinyl)-2,4,6-trimethoxyphenanthrene

There total 8 articles about (Z)-10-(1-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)vinyl)-2,4,6-trimethoxyphenanthrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

1-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)-1-(3,5,7-trimethoxyphenanthren-9-yl)ethanol (1400655-53-9) → (E)-10-(1-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)vinyl)-2,4,6-trimethoxyphenanthrene (1400655-48-2) + (Z)-10-(1-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)vinyl)-2,4,6-trimethoxyphenanthrene (1400655-58-4)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; at 20 ℃; for 4h;

DOI:10.1021/jo301345a

Reference yield:

3,5,7-trimethoxyphenanthrene-9-carbonitrile (1400655-51-7) → (E)-10-(1-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)vinyl)-2,4,6-trimethoxyphenanthrene (1400655-48-2) + (Z)-10-(1-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)vinyl)-2,4,6-trimethoxyphenanthrene (1400655-58-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 2-methoxy-ethanol; water; sodium hydroxide / 18 h / 150 °C

2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 25 °C

3: tetrahydrofuran / 3 h / 0 - 25 °C

4: tetrahydrofuran / 3 h / 0 - 25 °C

5: toluene-4-sulfonic acid / toluene / 4 h / 20 °C

With 2-methoxy-ethanol; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 3: |Grignard Reaction / 4: |Grignard Reaction;

DOI:10.1021/jo301345a

Reference yield:

3,5,7-trimethoxyphenanthrene-9-carboxylic Acid (1400655-50-6) → (E)-10-(1-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)vinyl)-2,4,6-trimethoxyphenanthrene (1400655-48-2) + (Z)-10-(1-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)vinyl)-2,4,6-trimethoxyphenanthrene (1400655-58-4)

Guidance literature:

Multi-step reaction with 4 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 25 °C

2: tetrahydrofuran / 3 h / 0 - 25 °C

3: tetrahydrofuran / 3 h / 0 - 25 °C

4: toluene-4-sulfonic acid / toluene / 4 h / 20 °C

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 2: |Grignard Reaction / 3: |Grignard Reaction;

DOI:10.1021/jo301345a

upstream raw materials:

(3,5-dimethoxyphenyl)(3,5,7-trimethoxyphenanthren-9-yl)methanone

1-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)-1-(3,5,7-trimethoxyphenanthren-9-yl)ethanol

3,5-dimethoxybenzyl bromide

2-bromo-1-(bromomethyl)-3,5-dimethoxybenzene