C₁₈H₁₆N₂S

Base Information

• Chemical Name: C₁₈H₁₆N₂S
• CAS No.: 1338225-44-7
• Molecular Formula: C₁₈H₁₆N₂S
• Molecular Weight: 292.404
• Mol file: 1338225-44-7.mol

Synonyms:C₁₈H₁₆N₂S

Chemical Property of C₁₈H₁₆N₂S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₁₆N₂S

There total 4 articles about C₁₈H₁₆N₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

C10H8N2S (1338225-43-6) + 2-methylbenzyl bromide (89-92-9) → C18H16N2S (1338225-44-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.08.009

Reference yield:

2-bromo-pyridine (109-04-6) → C18H16N2S (1338225-44-7)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; acetonitrile / 75 °C

2: pyridine; tetraphosphorus decasulfide / 120 °C

3: potassium carbonate / N,N-dimethyl-formamide

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetraphosphorus decasulfide; sodium carbonate; potassium carbonate; In water; N,N-dimethyl-formamide; acetonitrile; 1: Suzuki coupling;

DOI:10.1016/j.bmcl.2011.08.009

Reference yield:

2-hydroxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1054483-78-1) → C18H16N2S (1338225-44-7)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; acetonitrile / 75 °C

2: pyridine; tetraphosphorus decasulfide / 120 °C

3: potassium carbonate / N,N-dimethyl-formamide

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetraphosphorus decasulfide; sodium carbonate; potassium carbonate; In water; N,N-dimethyl-formamide; acetonitrile; 1: Suzuki coupling;

DOI:10.1016/j.bmcl.2011.08.009

upstream raw materials:

2-bromo-pyridine

2-hydroxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

5-(2-Pyridyl)-1,2-dihydropyridin-2-one

C₁₀H₈N₂S