7-ACETOXY-4-CHLORO-6-METHOXYQUINAZOLINE

Base Information

• Chemical Name: 7-ACETOXY-4-CHLORO-6-METHOXYQUINAZOLINE
• CAS No.: 179688-03-0
• Molecular Formula: C11H9 Cl N2 O3
• Molecular Weight: 252.65376
• Mol file: 179688-03-0.mol

Synonyms:7-Quinazolinol,4-chloro-6-methoxy-, acetate (ester) (9CI);7-Acetoxy-4-chloro-6-methoxyquinazoline

Chemical Property of 7-ACETOXY-4-CHLORO-6-METHOXYQUINAZOLINE

Chemical Property:

• Boiling Point: 364.6±37.0 °C(Predicted)
• PKA: 0.11±0.30(Predicted)
• PSA: 61.31000
• Density: 1.376±0.06 g/cm3(Predicted)
• LogP: 2.21710

Purity/Quality:

99% ^*data from raw suppliers

7-ACETOXY-4-CHLORO-6-METHOXYQUINAZOLINE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-ACETOXY-4-CHLORO-6-METHOXYQUINAZOLINE

There total 10 articles about 7-ACETOXY-4-CHLORO-6-METHOXYQUINAZOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

7-acetoxy-6-methoxy-3,4-dihydroquinazolin-4-one (179688-02-9) → 4-chloro-6-methoxyquinazolin-7-yl acetate (179688-03-0)

Guidance literature:

7-acetoxy-6-methoxy-3,4-dihydroquinazolin-4-one; With trichlorophosphate; In chloroform; at 20 - 70 ℃; for 1h;

With triethylamine; In chloroform; for 12h; Reflux;

DOI:10.1021/jm300042x

Reference yield: 93.0%

→ 4-chloro-6-methoxyquinazolin-7-yl acetate (179688-03-0)

Guidance literature:

Reference yield:

7-acetoxy-6-methoxyquinazolin-4-one → 4-chloro-6-methoxyquinazolin-7-yl acetate (179688-03-0)

Guidance literature:

With thionyl chloride; In N,N-dimethyl-formamide; at 90 ℃; for 4h;

upstream raw materials:

7-acetoxy-6-methoxy-3,4-dihydroquinazolin-4-one

7-hydroxy-6-methoxy-3,4-dihydroquinazolin-4-one

7-(benzyloxy)-6-methoxyquinazolin-4(3H)-one

4-hydroxy-3-methoxybenzoic acid methyl ester

Downstream raw materials:

acetic acid 4-(3-chloro-4-fluoro-phenylamino)-6-methoxy-quinazolin-7-yl ester

4-chloro-6-methoxy-quinazolin-7-ol

C₃₂H₃₈N₆O₅

C₂₁H₂₂ClN₃O₅