trifluoromethanesulfonic acid 4-(3-chloro-4-fluorophenylamino)-6-methoxy-7-quinazolinyl ester

Base Information

Chemical Name:trifluoromethanesulfonic acid 4-(3-chloro-4-fluorophenylamino)-6-methoxy-7-quinazolinyl ester
CAS No.:451494-89-6
Molecular Formula:C₁₆H₁₀ClF₄N₃O₄S
Molecular Weight:451.786
Hs Code.:

Synonyms:trifluoromethanesulfonic acid 4-(3-chloro-4-fluorophenylamino)-6-methoxy-7-quinazolinyl ester

Suppliers and Price of trifluoromethanesulfonic acid 4-(3-chloro-4-fluorophenylamino)-6-methoxy-7-quinazolinyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of trifluoromethanesulfonic acid 4-(3-chloro-4-fluorophenylamino)-6-methoxy-7-quinazolinyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of trifluoromethanesulfonic acid 4-(3-chloro-4-fluorophenylamino)-6-methoxy-7-quinazolinyl ester

There total 7 articles about trifluoromethanesulfonic acid 4-(3-chloro-4-fluorophenylamino)-6-methoxy-7-quinazolinyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 451494-91-0
4-((3-chloro-4-fluorophenyl)amino)-6-methoxyquinazolin-7-ol

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 451494-89-6
trifluoromethanesulfonic acid 4-(3-chloro-4-fluorophenylamino)-6-methoxy-7-quinazolinyl ester

Guidance literature:: With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 4h;
DOI:10.1016/j.tetlet.2005.08.123

Reference yield: 66.0%

: 451494-89-6
trifluoromethanesulfonic acid 4-(3-chloro-4-fluorophenylamino)-6-methoxy-7-quinazolinyl ester

Guidance literature:

Reference yield:

: 162012-72-8
7-hydroxy-6-methoxy-3,4-dihydroquinazolin-4-one

: 451494-89-6
trifluoromethanesulfonic acid 4-(3-chloro-4-fluorophenylamino)-6-methoxy-7-quinazolinyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / pyridine / 1 h / Heating

2: 69 percent / SOCl₂ / 1.5 h / Heating

3: 91 percent / i-PrOH / Heating

4: 90 percent / ammonia; methanol / 2 h / 20 °C

5: 88 percent / K₂CO₃ / tetrahydrofuran / 4 h / 20 °C

With pyridine; methanol; thionyl chloride; ammonia; potassium carbonate; isopropyl alcohol; In tetrahydrofuran;
DOI:10.1016/j.tetlet.2005.08.123