(S)-2-{(S)-4-Carboxy-2-[6-(2,4-dinitro-phenylamino)-hexanoylamino]-butyrylamino}-pentanedioic acid

Base Information

Chemical Name:(S)-2-{(S)-4-Carboxy-2-[6-(2,4-dinitro-phenylamino)-hexanoylamino]-butyrylamino}-pentanedioic acid
CAS No.:166321-88-6
Molecular Formula:C₂₂H₂₉N₅O₁₂
Molecular Weight:555.499
Hs Code.:

Synonyms:(S)-2-{(S)-4-Carboxy-2-[6-(2,4-dinitro-phenylamino)-hexanoylamino]-butyrylamino}-pentanedioic acid

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Chemical Property of (S)-2-{(S)-4-Carboxy-2-[6-(2,4-dinitro-phenylamino)-hexanoylamino]-butyrylamino}-pentanedioic acid

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Technology Process of (S)-2-{(S)-4-Carboxy-2-[6-(2,4-dinitro-phenylamino)-hexanoylamino]-butyrylamino}-pentanedioic acid

There total 5 articles about (S)-2-{(S)-4-Carboxy-2-[6-(2,4-dinitro-phenylamino)-hexanoylamino]-butyrylamino}-pentanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 166321-87-5
(S)-2-{(S)-4-tert-Butoxycarbonyl-2-[6-(2,4-dinitro-phenylamino)-hexanoylamino]-butyrylamino}-pentanedioic acid di-tert-butyl ester

: 166321-88-6
(S)-2-{(S)-4-Carboxy-2-[6-(2,4-dinitro-phenylamino)-hexanoylamino]-butyrylamino}-pentanedioic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ac00115a023

Reference yield:

: 16874-06-9
di-tert-butyl L-glutamate

: 166321-88-6
(S)-2-{(S)-4-Carboxy-2-[6-(2,4-dinitro-phenylamino)-hexanoylamino]-butyrylamino}-pentanedioic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / CH₂Cl₂

2: 100 percent / H₂ / 10percent Pd on carbon

3: 74 percent / dicyclohexylcarbodiimide, Hydroxybenzotriazole, diisopropylethylamine / dimethylformamide

4: 98 percent / trifluoroacetic acid / CH₂Cl₂

With hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ac00115a023

Reference yield:

: C₂₁H₂₆N₂O₈

: 166321-88-6
(S)-2-{(S)-4-Carboxy-2-[6-(2,4-dinitro-phenylamino)-hexanoylamino]-butyrylamino}-pentanedioic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / CH₂Cl₂

2: 100 percent / H₂ / 10percent Pd on carbon

3: 74 percent / dicyclohexylcarbodiimide, Hydroxybenzotriazole, diisopropylethylamine / dimethylformamide

4: 98 percent / trifluoroacetic acid / CH₂Cl₂

With hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ac00115a023