7-methoxy-3-(4-methylphenylsulfonyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

Base Information

Chemical Name:7-methoxy-3-(4-methylphenylsulfonyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol
CAS No.:81593-59-1
Molecular Formula:C₁₈H₂₁NO₄S
Molecular Weight:347.435
Hs Code.:

Synonyms:7-methoxy-3-(4-methylphenylsulfonyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

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Chemical Property of 7-methoxy-3-(4-methylphenylsulfonyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

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Technology Process of 7-methoxy-3-(4-methylphenylsulfonyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

There total 7 articles about 7-methoxy-3-(4-methylphenylsulfonyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 81593-57-9
7-methoxy-3-(4-methylphenylsulfonyl)-2,3,4,5-tetrahydro-3-benzazepin-1-one

: 81593-59-1
7-methoxy-3-(4-methylphenylsulfonyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

Guidance literature:: With sodium tetrahydroborate; In methanol; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1002/cmdc.201000005

Reference yield:

: 64880-89-3
N-[(3-methoxyphenyl)ethyl]-4′′-methylbenzenesulfonamide

: 81593-59-1
7-methoxy-3-(4-methylphenylsulfonyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: K₂CO₃ / acetone / 20 h / Heating

2: NaOH / ethanol; H₂O / 5 h / Heating

3: SOCl₂ / benzene / 8 h / Heating

4: 42 percent / AlCl₃ / CH₂Cl₂ / 1.) 5 h, -65 deg C, 2.) 12 h, room temp.

5: 68 percent / NaBH₄ / methanol / 1.) 1 h, room temp., 2.) 0.5 h, reflux

With sodium hydroxide; sodium tetrahydroborate; aluminium trichloride; thionyl chloride; potassium carbonate; In methanol; ethanol; dichloromethane; water; acetone; benzene;
DOI:10.1248/cpb.30.180

Reference yield:

: 81593-56-8
[[2-(3-Methoxy-phenyl)-ethyl]-(toluene-4-sulfonyl)-amino]-acetic acid

: 81593-59-1
7-methoxy-3-(4-methylphenylsulfonyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / benzene / 8 h / Heating

2: 42 percent / AlCl₃ / CH₂Cl₂ / 1.) 5 h, -65 deg C, 2.) 12 h, room temp.

3: 68 percent / NaBH₄ / methanol / 1.) 1 h, room temp., 2.) 0.5 h, reflux

With sodium tetrahydroborate; aluminium trichloride; thionyl chloride; In methanol; dichloromethane; benzene;
DOI:10.1248/cpb.30.180