N-(aminopyrazol-1-ylmethylene)-2-[2-(2-chlorophenyl)-5-(4-propoxyphenyl)pyrrol-1-yl]acetamide

Base Information

• Chemical Name: N-(aminopyrazol-1-ylmethylene)-2-[2-(2-chlorophenyl)-5-(4-propoxyphenyl)pyrrol-1-yl]acetamide
• CAS No.: 905971-91-7
• Molecular Formula: C₂₅H₂₄ClN₅O₂
• Molecular Weight: 461.951
• Mol file: 905971-91-7.mol

Synonyms:N-(aminopyrazol-1-ylmethylene)-2-[2-(2-chlorophenyl)-5-(4-propoxyphenyl)pyrrol-1-yl]acetamide

Chemical Property of N-(aminopyrazol-1-ylmethylene)-2-[2-(2-chlorophenyl)-5-(4-propoxyphenyl)pyrrol-1-yl]acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(aminopyrazol-1-ylmethylene)-2-[2-(2-chlorophenyl)-5-(4-propoxyphenyl)pyrrol-1-yl]acetamide

There total 5 articles about N-(aminopyrazol-1-ylmethylene)-2-[2-(2-chlorophenyl)-5-(4-propoxyphenyl)pyrrol-1-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chlorophenacyl bromide (5000-66-8) → N-(aminopyrazol-1-ylmethylene)-2-[2-(2-chlorophenyl)-5-(4-propoxyphenyl)pyrrol-1-yl]acetamide (905971-91-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 36 percent / ZnCl₂; Et₂NH / toluene; 2-methyl-propan-2-ol / 20 °C

2.1: 81 percent / AcOH / Heating

3.1: carbonyldiimidazole / CH₂Cl₂ / 20 °C

3.2: Et₃N; 4-dimethylaminopyridine / CH₂Cl₂ / 20 °C

With acetic acid; diethylamine; 1,1'-carbonyldiimidazole; zinc(II) chloride; In dichloromethane; toluene; tert-butyl alcohol;

DOI:10.1021/jm0607451

Reference yield:

[2-(2-chlorophenyl)-5-(4-propoxyphenyl)pyrrol-1-yl]acetic acid (912675-38-8) + 1H-pyrazole-1-carboximidamide hydrochloride (4023-02-3) → N-(aminopyrazol-1-ylmethylene)-2-[2-(2-chlorophenyl)-5-(4-propoxyphenyl)pyrrol-1-yl]acetamide (905971-91-7)

Guidance literature:

[2-(2-chlorophenyl)-5-(4-propoxyphenyl)pyrrol-1-yl]acetic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃;

1H-pyrazole-1-carboximidamide hydrochloride; With dmap; triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/jm0607451

Reference yield:

1-(2-chlorophenyl)-4-(4-propoxyphenyl)butane-1,4-dione (904686-43-7) → N-(aminopyrazol-1-ylmethylene)-2-[2-(2-chlorophenyl)-5-(4-propoxyphenyl)pyrrol-1-yl]acetamide (905971-91-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 81 percent / AcOH / Heating

2.1: carbonyldiimidazole / CH₂Cl₂ / 20 °C

2.2: Et₃N; 4-dimethylaminopyridine / CH₂Cl₂ / 20 °C

With acetic acid; 1,1'-carbonyldiimidazole; In dichloromethane;

DOI:10.1021/jm0607451

upstream raw materials:

[2-(2-chlorophenyl)-5-(4-propoxyphenyl)pyrrol-1-yl]acetic acid

1H-pyrazole-1-carboximidamide hydrochloride

1-(2-chlorophenyl)-4-(4-propoxyphenyl)butane-1,4-dione

2-chlorophenacyl bromide

Downstream raw materials:

C₂₇H₃₁ClN₄O₄

C₂₇H₂₇ClN₄O₂S

C₂₈H₃₁ClN₆O₂

C₂₇H₂₇ClN₄O₃