CID 10909711

Base Information

• Chemical Name: CID 10909711
• CAS No.: 4023-02-3
• Molecular Formula: C4H6N4^.HCl
• Molecular Weight: 146.579
• Hs Code.: 29339900
• Mol file: 4023-02-3.mol

Synonyms:

Chemical Property of CID 10909711

Chemical Property:

• Appearance/Colour: white to light yellow crystals or crystalline
• Vapor Pressure: 0.00111mmHg at 25°C
• Melting Point: 167-170 °C(lit.)
• Boiling Point: 891.5oC at 760 mmHg。 产品描述 安全性：
• Flash Point: 493oC
• PSA: 67.69000
• Density: 2.2 g/cm3
• LogP: 1.22670
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility.: Soluble
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 146.0359239
• Heavy Atom Count: 9
• Complexity: 94.7

Purity/Quality:

98% ^*data from raw suppliers

1H-Pyrazole-1-carboxamidine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,C
• Statements: 36/37/38-36/37-34
• Safety Statements: 26-37/39-45-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CN(N=C1)C(=[NH2+])N.[Cl-]
• Uses: 1H-Pyrazole-1-carboxamidine hydrochloride may be used in the following studies: ? Preparation of guanidylated hollow fiber membranes. ? Guanylation of amines and in peptide synthesis. ? Synthesis of bis-guanidinium-cholesterol derivatives. 1H-Pyrazole-1-carboxamidine hydrochloride is a stable and versatile reagent for the efficient and chemically specific guanylation of sterically unhindered primary and secondary aliphatic amines under mild conditions. 1H-Pyrazole-1-carboxamidine hydrochloride is a useful reagent in peptide synthesis

Technology Process of CID 10909711

There total 6 articles about CID 10909711 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyl (1H-pyrazol-1-ylcarbonoimidoyl)carbamate (152120-61-1) → 1H-pyrazole-1-carboximidamide hydrochloride (4023-02-3)

Guidance literature:

With sulfuric acid; sodium chloride; In neat (no solvent); at 20 ℃; for 3h; Sealed tube;

DOI:10.1039/d1ob00728a

Reference yield: 98.0%

CYANAMID (420-04-2) + 1H-pyrazole hydrochloride (35877-22-6) → 1H-pyrazole-1-carboximidamide hydrochloride (4023-02-3)

Guidance literature:

at 80 ℃; for 0.1h;

DOI:10.1016/j.tetlet.2004.10.114

Reference yield: 95.0%

NH-pyrazole (288-13-1) + CYANAMID (420-04-2) → 1H-pyrazole-1-carboximidamide hydrochloride (4023-02-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 2h; Heating;

DOI:10.1021/jo00034a059

upstream raw materials:

NH-pyrazole

CYANAMID

1H-pyrazole hydrochloride

malonaldehydebis(dimethylacetal)

Refernces

• 1、 De Borggraeve, Wim M.,Gilles, Philippe,Van Mileghem, Seger,Verschueren, Rik H.. "Solvent-freeN-Boc deprotection byex situgeneration of hydrogen chloride gas". supporting information. p. 5782 - 5787. Retrieved 2021/07/12.
• 2、 -. "PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS". . . Retrieved 2010/03/02.