(R)-methyl 7-((tert-butyldiphenylsilyl)oxy)-8-((4-methoxybenzyl)oxy)oct-4-ynoate

Base Information

Chemical Name:(R)-methyl 7-((tert-butyldiphenylsilyl)oxy)-8-((4-methoxybenzyl)oxy)oct-4-ynoate
CAS No.:1434154-42-3
Molecular Formula:C₃₃H₄₀O₅Si
Molecular Weight:544.763
Hs Code.:

Synonyms:(R)-methyl 7-((tert-butyldiphenylsilyl)oxy)-8-((4-methoxybenzyl)oxy)oct-4-ynoate

Suppliers and Price of (R)-methyl 7-((tert-butyldiphenylsilyl)oxy)-8-((4-methoxybenzyl)oxy)oct-4-ynoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-methyl 7-((tert-butyldiphenylsilyl)oxy)-8-((4-methoxybenzyl)oxy)oct-4-ynoate

Chemical Property:

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Technology Process of (R)-methyl 7-((tert-butyldiphenylsilyl)oxy)-8-((4-methoxybenzyl)oxy)oct-4-ynoate

There total 5 articles about (R)-methyl 7-((tert-butyldiphenylsilyl)oxy)-8-((4-methoxybenzyl)oxy)oct-4-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₂H₃₈O₅Si

: 74-88-4
methyl iodide

: 1434154-42-3
(R)-methyl 7-((tert-butyldiphenylsilyl)oxy)-8-((4-methoxybenzyl)oxy)oct-4-ynoate

Guidance literature:: With potassium carbonate; In acetone; at 20 ℃; for 20h;
DOI:10.1021/jo4004647

Reference yield:

: 1434154-40-1
(R)-triisopropylsilyl 7-((tert-butyldiphenylsilyl)-oxy)-8-((4-methoxybenzyl)oxy)oct-4-ynoate

: 1434154-42-3
(R)-methyl 7-((tert-butyldiphenylsilyl)oxy)-8-((4-methoxybenzyl)oxy)oct-4-ynoate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / tetrahydrofuran; water / 16 h / 20 °C

2: potassium carbonate / acetone / 20 h / 20 °C

With potassium carbonate; In tetrahydrofuran; water; acetone;
DOI:10.1021/jo4004647

Reference yield:

: 80910-01-6,108836-41-5,144069-33-0,134733-19-0
(R)-2-(((4-methoxybenzyl)oxy)methyl)oxirane

: 1434154-42-3
(R)-methyl 7-((tert-butyldiphenylsilyl)oxy)-8-((4-methoxybenzyl)oxy)oct-4-ynoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 2.17 h / -78 °C / Inert atmosphere

2.1: 1H-imidazole / dichloromethane / 2 h / 20 °C / Inert atmosphere

3.1: potassium carbonate / tetrahydrofuran; water / 16 h / 20 °C

4.1: potassium carbonate / acetone / 20 h / 20 °C

With 1H-imidazole; n-butyllithium; potassium carbonate; In tetrahydrofuran; dichloromethane; water; acetone;
DOI:10.1021/jo4004647