2-(4-Bromothiophen-2-yl)-1,3-dioxolane

Base Information

• Chemical Name: 2-(4-Bromothiophen-2-yl)-1,3-dioxolane
• CAS No.: 58267-85-9
• Molecular Formula: C7H7BrO2S
• Molecular Weight: 235.101
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID80397425
• Nikkaji Number: J150.210G
• Wikidata: Q82198743
• Mol file: 58267-85-9.mol

Synonyms:58267-85-9;2-(4-bromothiophen-2-yl)-1,3-dioxolane;2-(4-BROMOTHIENYL)-1,3-DIOXOLANE;4-BROMOTHIOPHENE-2-CARBOXALDEHYDE ETHYLENE GLYCOL ACETAL;2-(4-Bromothien-2-yl)-1,3-dioxolane;2-(4-bromo-2-thienyl)-1,3-dioxolane;1,3-Dioxolane, 2-(4-bromo-2-thienyl)-;SCHEMBL1680716;DTXSID80397425;GDNOSUAFGZBAOR-UHFFFAOYSA-N;MFCD04117938;AKOS026675536;AB20764;PS-6078;CS-0129035;2-(4-bromo-thiophen-2-yl)-[1,3]dioxolane;E89780;EN300-223101;Z1269189208;4-BROMOTHIOPHENE-2-CARBOXALDEHYDEETHYLENEGLYCOLACETAL

Chemical Property of 2-(4-Bromothiophen-2-yl)-1,3-dioxolane

Chemical Property:

• Vapor Pressure: 0.00352mmHg at 25°C
• Refractive Index: 1.591
• Boiling Point: 290.8 °C at 760 mmHg
• Flash Point: 129.7 °C
• PSA: 46.70000
• Density: 1.671 g/cm³
• LogP: 2.55600
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 233.93501
• Heavy Atom Count: 11
• Complexity: 138

Purity/Quality:

98%min ^*data from raw suppliers

2-(4-Bromothien-2-yl)-1,3-dioxolane ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC(O1)C2=CC(=CS2)Br

Technology Process of 2-(4-Bromothiophen-2-yl)-1,3-dioxolane

There total 3 articles about 2-(4-Bromothiophen-2-yl)-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.2%

4-Bromothiophen-2-aldehyde (18791-75-8) + ethylene glycol (107-21-1) → 2-(4-bromo-thiophen-2-yl)-[1,3]dioxolane (58267-85-9)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 8h; Reflux;

Reference yield: 98.0%

4-Bromothiophen-2-aldehyde (18791-75-8) → 2-(4-bromo-thiophen-2-yl)-[1,3]dioxolane (58267-85-9)

Guidance literature:

With toluene-4-sulfonic acid; In ethylene glycol; toluene;

Reference yield:

→ 2-(4-bromo-thiophen-2-yl)-[1,3]dioxolane (58267-85-9)

Guidance literature:

Aldehyd 6a, Δ mit Ethylenglykol/Benzol/TsOH;

DOI:10.1021/jo00870a005

upstream raw materials:

4-Bromothiophen-2-aldehyde

ethylene glycol

Downstream raw materials:

4-iodothiophene-2-carbaldehyde

2-(4-(3-fluoro-phenoxy)-thiophen-2-yl)-[1,3]dioxolane

3-carboxy-thiophene-5-carboxaldehyde

1-[4-(3-bromo-5-[1,3]dioxolan-2-ylthiophen-2-yl)-phenyl]-propan-1-one