4-Iodo-2-thiophenecarbaldehyde

Base Information

• Chemical Name: 4-Iodo-2-thiophenecarbaldehyde
• CAS No.: 18812-38-9
• Molecular Formula: C5H3IOS
• Molecular Weight: 238.049
• Hs Code.: 2934999090
• Mol file: 18812-38-9.mol

Synonyms:4-Iodo-2-thiophenecarbaldehyde;4-Iodothiophene-2-carbaldehyde

Chemical Property of 4-Iodo-2-thiophenecarbaldehyde

Chemical Property:

• Boiling Point: 297.953 °C at 760 mmHg
• Flash Point: 133.998 °C
• PSA: 45.31000
• Density: 2.113 g/cm³
• LogP: 2.16520
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

4-Iodothiophene-2-carbaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Iodo-2-thiophenecarbaldehyde

There total 1 articles about 4-Iodo-2-thiophenecarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-(4-bromo-thiophen-2-yl)-[1,3]dioxolane (58267-85-9) → 4-iodothiophene-2-carbaldehyde (18812-38-9)

Guidance literature:

2-(4-bromo-thiophen-2-yl)-[1,3]dioxolane; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.333333h;

With iodine; In diethyl ether; hexane; at 20 ℃; for 0.333333h;

With hydrogenchloride; In diethyl ether; hexane; water;

Reference yield:

4-iodothiophene-2-carbaldehyde (18812-38-9) + 2,2-difluoro-2-(fluorosulfonyl)acetate (680-15-9) → 4-(trifluoromethyl)thiophene-2-carbaldehyde

Guidance literature:

With copper(l) iodide; In N,N-dimethyl-formamide; at 100 ℃; for 16h; Inert atmosphere;

Reference yield:

4-iodothiophene-2-carbaldehyde (18812-38-9) + 2,2-difluoro-2-(fluorosulfonyl)acetate (680-15-9) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → N-methoxy-N-methyl-4-(trifluoromethyl)thiophene-2-carboxamide

Guidance literature:

4-iodothiophene-2-carbaldehyde; 2,2-difluoro-2-(fluorosulfonyl)acetate; With copper(l) iodide; In N,N-dimethyl-formamide; at 100 ℃; for 16h; Inert atmosphere;

With potassium permanganate; sodium dihydrogenphosphate; In methanol; water; at 15 ℃; for 2h;

N,O-dimethylhydroxylamine*hydrochloride; With triethylamine; HATU; In N,N-dimethyl-formamide; at 10 ℃; for 2h;

upstream raw materials:

2-(4-bromo-thiophen-2-yl)-[1,3]dioxolane

Downstream raw materials:

4-iodothiophene-2-carboxylic acid

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