di-tert-butyl (5-bromo-3-(3-(4-(chloromethyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)carbamate

Base Information

• Chemical Name: di-tert-butyl (5-bromo-3-(3-(4-(chloromethyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)carbamate
• CAS No.: 1349734-86-6
• Molecular Formula: C₂₄H₂₆BrClN₄O₅
• Molecular Weight: 565.851
• Mol file: 1349734-86-6.mol

Synonyms:di-tert-butyl (5-bromo-3-(3-(4-(chloromethyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)carbamate

Chemical Property of di-tert-butyl (5-bromo-3-(3-(4-(chloromethyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of di-tert-butyl (5-bromo-3-(3-(4-(chloromethyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)carbamate

There total 8 articles about di-tert-butyl (5-bromo-3-(3-(4-(chloromethyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

(1Z)-4-(chloromethyl)-N-hydroxybenzimidoyl chloride + tert-butyl N-(5-bromo-3-ethynyl-pyrazin-2-yl)-N-tert-butoxycarbonyl-carbamate (1232423-55-0) → di-tert-butyl (5-bromo-3-(3-(4-(chloromethyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)carbamate (1349734-86-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 18h;

Reference yield: 66.0%

tert-butyl N-(5-bromo-3-ethynyl-pyrazin-2-yl)-N-tert-butoxycarbonyl-carbamate (1232423-55-0) + (Z)-4-(chloromethyl)-N-hydroxy-benzimidoyl chloride (1349734-84-4) → di-tert-butyl (5-bromo-3-(3-(4-(chloromethyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)carbamate (1349734-86-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

4-chloromethylbenzaldehyde (73291-09-5) → di-tert-butyl (5-bromo-3-(3-(4-(chloromethyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)carbamate (1349734-86-6)

Guidance literature:

Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride / ethanol / 3 h / 50 °C

2: N-chloro-succinimide; hydrogenchloride / N,N-dimethyl-formamide; 1,4-dioxane / 0.5 h / 20 °C

3: triethylamine / dichloromethane / 18 h / 20 °C

With hydrogenchloride; N-chloro-succinimide; hydroxylamine hydrochloride; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

4-chloromethylbenzaldehyde

4-(hydroxymethyl)benzyl chloride

5-bromo-3-((trimethylsilyl)ethynyl)pyrazine-2-amine

(1E)-4-(chloromethyl)benzaldehyde oxime

Downstream raw materials:

1-((4-(5-(3-amino-6-bromopyrazin-2-yl)isoxazol-3-yl)benzyl)amino)-2-methylpropan-2-ol

5-bromo-3-(3-(4-(chloromethyl)phenyl)isoxazol-5-yl)pyrazin-2-amine

C₂₈H₃₄BrN₅O₆

C₃₇H₄₃N₇O₆