5-[1-amino-2-(3-fluorophenyl)-ethyl]-3-(3-methyl-but-2-enyl)-dihydrofuran-2-one, tosylate salt

Base Information

Chemical Name:5-[1-amino-2-(3-fluorophenyl)-ethyl]-3-(3-methyl-but-2-enyl)-dihydrofuran-2-one, tosylate salt
CAS No.:624736-62-5
Molecular Formula:C₇H₈O₃S*C₁₇H₂₂FNO₂
Molecular Weight:463.57
Hs Code.:

Synonyms:5-[1-amino-2-(3-fluorophenyl)-ethyl]-3-(3-methyl-but-2-enyl)-dihydrofuran-2-one, tosylate salt

Suppliers and Price of 5-[1-amino-2-(3-fluorophenyl)-ethyl]-3-(3-methyl-but-2-enyl)-dihydrofuran-2-one, tosylate salt

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-[1-amino-2-(3-fluorophenyl)-ethyl]-3-(3-methyl-but-2-enyl)-dihydrofuran-2-one, tosylate salt

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-[1-amino-2-(3-fluorophenyl)-ethyl]-3-(3-methyl-but-2-enyl)-dihydrofuran-2-one, tosylate salt

There total 4 articles about 5-[1-amino-2-(3-fluorophenyl)-ethyl]-3-(3-methyl-but-2-enyl)-dihydrofuran-2-one, tosylate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 104-15-4
toluene-4-sulfonic acid

: 379216-93-0
tert-butyl (S)-2-(3-fluorophenyl)-1-((2S,4R)-tetrahydro-4-(3-methylbut-2-enyl)-5-oxofuran-2-yl)ethylcarbamate

: 624736-62-5
5-[1-amino-2-(3-fluorophenyl)-ethyl]-3-(3-methyl-but-2-enyl)-dihydrofuran-2-one, tosylate salt

Guidance literature:: With water; In ethyl acetate; at 20 ℃; for 2 - 12h;

Reference yield:

: 379216-93-0
tert-butyl (S)-2-(3-fluorophenyl)-1-((2S,4R)-tetrahydro-4-(3-methylbut-2-enyl)-5-oxofuran-2-yl)ethylcarbamate

: 624736-62-5
5-[1-amino-2-(3-fluorophenyl)-ethyl]-3-(3-methyl-but-2-enyl)-dihydrofuran-2-one, tosylate salt

Guidance literature:: With toluene-4-sulfonic acid; In water; ethyl acetate; at 60 ℃;
DOI:10.1021/op050059w

Reference yield:

: 344620-59-3
5-[(1S)-N-Boc-amino-(2S)-(3-fluorophenyl)ethyl]dihydrofuran-2-one

: 624736-62-5
5-[1-amino-2-(3-fluorophenyl)-ethyl]-3-(3-methyl-but-2-enyl)-dihydrofuran-2-one, tosylate salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 - -65 °C / Inert atmosphere

1.2: 0.03 h / -78 - -70 °C

2.1: toluene-4-sulfonic acid / ethyl acetate; water / 60 °C

With toluene-4-sulfonic acid; lithium hexamethyldisilazane; In tetrahydrofuran; water; ethyl acetate;
DOI:10.1021/op050059w