tert-butyl N-[(1S)-2-(3-fluorophenyl)-1-[(2S,4R)-4-(3-methylbut-2-enyl)-5-oxooxolan-2-yl]ethyl]carbamate

Base Information

Chemical Name:tert-butyl N-[(1S)-2-(3-fluorophenyl)-1-[(2S,4R)-4-(3-methylbut-2-enyl)-5-oxooxolan-2-yl]ethyl]carbamate
CAS No.:379216-93-0
Molecular Formula:C₂₂H₃₀FNO₄
Molecular Weight:391.483
Hs Code.:
DSSTox Substance ID:DTXSID101103896
Nikkaji Number:J2.411.781B

Synonyms:DTXSID101103896;379216-93-0;1,1-Dimethylethyl N-[(1S)-2-(3-fluorophenyl)-1-[(2S,4R)-tetrahydro-4-(3-methyl-2-buten-1-yl)-5-oxo-2-furanyl]ethyl]carbamate

Suppliers and Price of tert-butyl N-[(1S)-2-(3-fluorophenyl)-1-[(2S,4R)-4-(3-methylbut-2-enyl)-5-oxooxolan-2-yl]ethyl]carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl N-[(1S)-2-(3-fluorophenyl)-1-[(2S,4R)-4-(3-methylbut-2-enyl)-5-oxooxolan-2-yl]ethyl]carbamate

Chemical Property:

XLogP3:5.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:391.21588660
Heavy Atom Count:28
Complexity:580

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=CCC1CC(OC1=O)C(CC2=CC(=CC=C2)F)NC(=O)OC(C)(C)C)C
Isomeric SMILES:CC(=CC[C@@H]1C[C@H](OC1=O)[C@H](CC2=CC(=CC=C2)F)NC(=O)OC(C)(C)C)C

Technology Process of tert-butyl N-[(1S)-2-(3-fluorophenyl)-1-[(2S,4R)-4-(3-methylbut-2-enyl)-5-oxooxolan-2-yl]ethyl]carbamate

There total 1 articles about tert-butyl N-[(1S)-2-(3-fluorophenyl)-1-[(2S,4R)-4-(3-methylbut-2-enyl)-5-oxooxolan-2-yl]ethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.3%

: 870-63-3
prenyl bromide

: 344620-59-3
5-[(1S)-N-Boc-amino-(2S)-(3-fluorophenyl)ethyl]dihydrofuran-2-one

: 379216-93-0
tert-butyl (S)-2-(3-fluorophenyl)-1-((2S,4R)-tetrahydro-4-(3-methylbut-2-enyl)-5-oxofuran-2-yl)ethylcarbamate

Guidance literature:: 5-[(1S)-N-Boc-amino-(2S)-(3-fluorophenyl)ethyl]dihydrofuran-2-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - -65 ℃; for 0.5h; Inert atmosphere; Large scale; Green chemistry;

prenyl bromide; With 1,3-dimethyl-2-imidazolidinone; In tetrahydrofuran; at -85 - -72 ℃; for 0.2h; diastereoselective reaction; Inert atmosphere; Large scale; Green chemistry;
DOI:10.1021/op010224h