344620-59-3

Upstream product

• 114873-01-7 N-Boc-3-fluoro-L-phenylalanine 
• 686718-73-0 2-tert-butoxycarbonylamino-L-3-(3-fluorophenyl)-thiopropionic acid S-propyl ester 
• 686718-74-1 5-tert-butoxycarbonylamino-L-6-(3-fluorophenyl)-4-oxo-hexanoic acid ethyl ester 

Downstream Products

• 379216-93-0 tert-butyl (S)-2-(3-fluorophenyl)-1-((2S,4R)-tetrahydro-4-(3-methylbut-2-enyl)-5-oxofuran-2-yl)ethylcarbamate 
• 624736-62-5 5-[1-amino-2-(3-fluorophenyl)-ethyl]-3-(3-methyl-but-2-enyl)-dihydrofuran-2-one, tosylate salt 
• 624736-63-6 quinoxaline-2-carboxylic acid {2-(3-fluorophenyl)-1-[4-(3-methyl-but-2-enyl)-5-oxo-tetrahydrofuran-2-yl]-ethyl}-amide 
• 624736-64-7 trifluoro-acetic acid 3-(5-{2-(3-fluoro-phenyl)-1-[(quinoxaline-2-carbonyl)-amino]-ethyl}-2-oxo-tetrahydrofuran-3-yl)-1,1-dimethyl-propyl ester 
• 212790-31-3 CP 481715 

Relevant academic research and scientific papers

Stereoselective synthesis of 5-[(1S)-N-Boc-amino-(2S)-(3-fluorophenyl) ethyl]-dihydrofuran-2-one

Phthalic anhydride as thiolate scavenger effectively preserved the enantiopurity of α-aminoketone, thus affording the convenient synthesis of the titled lactone. A short, efficient, and highly diastereoselective synthesis of 5-[(1S)-N-Boc-amino-(2S)-(3-fluorophenyl)ethyl]-dihydrofuran-2-one (1) is described. Use of phthalic anhydride as thiolate scavenger effectively preserves the chiral integrity of the α-aminoketone 4 product obtained from the reaction of organozincate 3 with thioester 2.

METHODS FOR MANUFACTURE OF DIHYDRO-FURAN-2-ONE DERIVATIVES

This invention relates to dihydro-furan-2-one derivatives, their intermediates and methods of manufacture. As such, the present invention includes methods of making a compound of the formula (V-1), wherein R2 and p are herein defined. The prese