(S)-3,4-DIHYDROXYBUTYRAMIDE

Base Information

• Chemical Name: (S)-3,4-DIHYDROXYBUTYRAMIDE
• CAS No.: 126495-84-9
• Molecular Formula: C4H9 N O3
• Molecular Weight: 119.12
• Mol file: 126495-84-9.mol

Synonyms:Butanamide,3,4-dihydroxy-, (S)-; (S)-3,4-Dihydroxybutyramide

Chemical Property of (S)-3,4-DIHYDROXYBUTYRAMIDE

Chemical Property:

• Boiling Point: 471.9±35.0 °C(Predicted)
• PKA: 14.02±0.20(Predicted)
• PSA: 83.55000
• Density: 1.312±0.06 g/cm3(Predicted)
• LogP: -1.08470

Purity/Quality:

99% ^*data from raw suppliers

(3S)-3,4-DIHYDROXYBUTANAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-3,4-DIHYDROXYBUTYRAMIDE

There total 1 articles about (S)-3,4-DIHYDROXYBUTYRAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3S)-hydroxy-γ-butyrolactone (5469-16-9,58081-05-3,131432-37-6,7331-52-4) → (S)-3,4-dihydroxybutyramide (126495-84-9)

Guidance literature:

With ammonium hydroxide; at 20 ℃; for 14h;

DOI:10.1021/jo9818226

Reference yield: 100.0%

2,2-dimethoxy-propane (77-76-9) + (S)-3,4-dihydroxybutyramide (126495-84-9) → (S)-4-(2,2-dimethyl)-1,3-dioxolane acetamide (185996-33-2)

Guidance literature:

2,2-dimethoxy-propane; (S)-3,4-dihydroxybutyramide; sulfuric acid; In acetone; at 20 - 60 ℃; for 12.5h;

With silver(l) oxide; In acetone; for 1h; Product distribution / selectivity;

Reference yield: 91.0%

trityl chloride (76-83-5) + (S)-3,4-dihydroxybutyramide (126495-84-9) → (S)-3-hydroxy-4-triphenylmethoxybutanamide (330555-58-3)

Guidance literature:

With pyridine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 36h;

DOI:10.1016/S0957-4166(00)00438-9

upstream raw materials:

(3S)-hydroxy-γ-butyrolactone

Downstream raw materials:

(S)-4-(2,2-dimethyl)-1,3-dioxolane acetamide

(S)-3-hydroxy-4-triphenylmethoxybutanamide

Refernces

• 1、 -. "PROCESS FOR THE PREPARATION OF PROTECTED DIHYDROXYPROPYL TRIALKYLAMMONIUM SALTS AND DERIVATIVES THEREOF". Page/Page column 5; 7; 8-9. . Retrieved 2008/06/13.