doxorubicin-succinimidyl 4-[N-maleimidomethyl]cyclohexane-1-carboxylate

Base Information

Chemical Name:doxorubicin-succinimidyl 4-[N-maleimidomethyl]cyclohexane-1-carboxylate
CAS No.:400647-59-8
Molecular Formula:C₃₉H₄₂N₂O₁₄
Molecular Weight:762.767
Hs Code.:

Synonyms:doxorubicin-succinimidyl 4-[N-maleimidomethyl]cyclohexane-1-carboxylate

Suppliers and Price of doxorubicin-succinimidyl 4-[N-maleimidomethyl]cyclohexane-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

BroadPharm
N-(4-((2,5-dioxo-2H-pyrrol-1(5H)-yl)methyl)cyclohexane)-Doxorubicin 98%
250 MG
$ 2500.00

BroadPharm
N-(4-((2,5-dioxo-2H-pyrrol-1(5H)-yl)methyl)cyclohexane)-Doxorubicin 98%
100 MG
$ 1400.00

BroadPharm
N-(4-((2,5-dioxo-2H-pyrrol-1(5H)-yl)methyl)cyclohexane)-Doxorubicin 98%
50 MG
$ 780.00

Total 6 raw suppliers

Chemical Property of doxorubicin-succinimidyl 4-[N-maleimidomethyl]cyclohexane-1-carboxylate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

N-(4-((2,5-dioxo-2H-pyrrol-1(5H)-yl)methyl)cyclohexane)-Doxorubicin 98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Doxorubicin-SMCC is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Description N-(4-((2,5-dioxo-2H-pyrrol-1(5H)-yl)methyl)cyclohexane)-Doxorubicin is a maleimide attached Doxorubicin. It can conjugate with thiol containing molecules.

Technology Process of doxorubicin-succinimidyl 4-[N-maleimidomethyl]cyclohexane-1-carboxylate

There total 5 articles about doxorubicin-succinimidyl 4-[N-maleimidomethyl]cyclohexane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 64987-85-5
4-(N-maleimidomethyl)cyclohexane-1-carboxylic acid N-succinimidyl ester

: 25316-40-9
doxorubicin hydrochloride

: 400647-59-8
doxorubicin-succinimidyl 4-[N-maleimidomethyl]cyclohexane-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1081/SCC-120039494

Reference yield: 90.0%

: 23214-92-8
doxorubicin

: sulfosuccinimidyl 4-[N-maleimidomethyl]-cyclohexane-1-carboxylate

: 400647-59-8
doxorubicin-succinimidyl 4-[N-maleimidomethyl]cyclohexane-1-carboxylate

Guidance literature:: With triethylamine; In dimethyl sulfoxide; at 20 ℃; for 12h; Inert atmosphere; Darkness;
DOI:10.1039/c4ob01153h

Reference yield: 89.0%

: N-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate

: 25316-40-9
doxorubicin hydrochloride

: 400647-59-8
doxorubicin-succinimidyl 4-[N-maleimidomethyl]cyclohexane-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 14h; Inert atmosphere; Darkness;
DOI:10.1002/jps.24631