(R)-3-ACETOXY-GAMMA-BUTYROLACTONE

Base Information

• Chemical Name: (R)-3-ACETOXY-GAMMA-BUTYROLACTONE
• CAS No.: 138666-02-1
• Molecular Formula: C₆H₈O₄
• Molecular Weight: 144.127
• Hs Code.: 2932190090
• Mol file: 138666-02-1.mol

Synonyms:2(3H)-Furanone,4-(acetyloxy)dihydro-, (R)-; (+)-4-(Acetoxy)-2,3-dihydro-2(3H)-furanone

Chemical Property of (R)-3-ACETOXY-GAMMA-BUTYROLACTONE

Chemical Property:

• PSA: 52.60000
• LogP: -0.13500

Purity/Quality:

99% ^*data from raw suppliers

(R)-3-ACETOXY-GAMMA-BUTYROLACTONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-3-ACETOXY-GAMMA-BUTYROLACTONE

There total 12 articles about (R)-3-ACETOXY-GAMMA-BUTYROLACTONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

peracetic acid (79-21-0) + but-3-enoic acid (625-38-7) → (S)-β-acetoxy-γ-butyrolactone (19405-98-2,128032-77-9,138666-02-1)

Guidance literature:

With trifluorormethanesulfonic acid; In acetic acid; at 20 ℃; Cooling with ice;

DOI:10.1021/jo202491y

Reference yield: 95.0%

(3-oxocyclobutyl) acetate (63930-59-6) → (S)-β-acetoxy-γ-butyrolactone (19405-98-2,128032-77-9,138666-02-1)

Guidance literature:

With lithium(etherate)2.5 tetrakis(pentafluorophenyl)borate; dihydrogen peroxide; oxalic acid; In 1,2-dichloro-ethane; at 20 ℃; for 2h;

DOI:10.1002/anie.201204286

Reference yield: 92.0%

but-3-enoic acid (625-38-7) + acetic anhydride (108-24-7) → (S)-β-acetoxy-γ-butyrolactone (19405-98-2,128032-77-9,138666-02-1)

Guidance literature:

acetic anhydride; With peracetic acid; dihydrogen peroxide; acetic acid; In water; at 0 - 20 ℃;

but-3-enoic acid; With palladium diacetate; In water; at 20 ℃; for 1h;

DOI:10.1021/ol1001686

upstream raw materials:

but-3-enoic acid

[bis(acetoxy)iodo]benzene

acetic acid

but-3-enenitrile

Downstream raw materials:

(3S)-hydroxy-γ-butyrolactone