2-Iodo-N-methylbenzenesulfonamide

Base Information

• Chemical Name: 2-Iodo-N-methylbenzenesulfonamide
• CAS No.: 125259-03-2
• Molecular Formula: C₇H₈INO₂S
• Molecular Weight: 297.117
• Mol file: 125259-03-2.mol

Synonyms:2-Iodo-N-methylbenzenesulfonamide

Chemical Property of 2-Iodo-N-methylbenzenesulfonamide

Chemical Property:

• Melting Point: 119-121 °C(Solv: methanol (67-56-1); water (7732-18-5))
• Boiling Point: 358.2±44.0 °C(Predicted)
• Density: 1.832±0.06 g/cm3(Predicted)

Purity/Quality:

95% ^*data from raw suppliers

2-Iodo-N-methyl-benzenesulfonamide 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Iodo-N-methylbenzenesulfonamide

There total 3 articles about 2-Iodo-N-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-iodobenzene-1-sulfonyl chloride (63059-29-0) + methylamine (74-89-5) → 2-Iodo-N-methylbenzenesulfonamide (125259-03-2)

Guidance literature:

In tetrahydrofuran; water; at 20 ℃; for 3h;

DOI:10.1016/j.bmcl.2020.127761

Reference yield:

2-amino-1-benzenesulfonic acid (88-21-1) → 2-Iodo-N-methylbenzenesulfonamide (125259-03-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium carbonate / water

1.2: 0.75 h / 0 °C

2.1: phosphorus pentachloride; trichlorophosphate / neat (no solvent) / 120 °C

3.1: 1,4-dioxane / 20 °C

With phosphorus pentachloride; sodium carbonate; trichlorophosphate; In 1,4-dioxane; water;

DOI:10.1002/anie.202013275

Reference yield:

2-iodobenzenesulfonic acid (63059-25-6) → 2-Iodo-N-methylbenzenesulfonamide (125259-03-2)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorus pentachloride; trichlorophosphate / neat (no solvent) / 120 °C

2: 1,4-dioxane / 20 °C

With phosphorus pentachloride; trichlorophosphate; In 1,4-dioxane;

DOI:10.1002/anie.202013275

upstream raw materials:

2-iodobenzene-1-sulfonyl chloride

methylamine

2-amino-1-benzenesulfonic acid

2-iodobenzenesulfonic acid

Downstream raw materials:

2-(2-Methylaminosulfonylphenylthio)benzoic acid

2-(5-cyano-pent-1-ynyl)-4,N-dimethyl-benzenesulfonamide

2-(2-Methylsulfamoyl-benzenesulfinyl)-benzoic acid

N-methyl-2-(phenylethynyl)benzenesulfonamide