2-Trimethylsilanyl-ethanesulfonic acid [(S)-1-[(3S,6R,7S)-3-(4-benzyloxy-benzyl)-6-(tert-butyl-dimethyl-silanyloxy)-7-chloro-[1,4]oxazocane-4-carbonyl]-4-(2-oxo-4,5-diphenyl-oxazol-3-yl)-butyl]-amide

Base Information

Chemical Name:2-Trimethylsilanyl-ethanesulfonic acid [(S)-1-[(3S,6R,7S)-3-(4-benzyloxy-benzyl)-6-(tert-butyl-dimethyl-silanyloxy)-7-chloro-[1,4]oxazocane-4-carbonyl]-4-(2-oxo-4,5-diphenyl-oxazol-3-yl)-butyl]-amide
CAS No.:183794-37-8
Molecular Formula:C₅₁H₆₈ClN₃O₈SSi₂
Molecular Weight:974.806
Hs Code.:

2-Trimethylsilanyl-ethanesulfonic acid [(S)-1-[(3S,6R,7S)-3-(4-benzyloxy-benzyl)-6-(tert-butyl-dimethyl-silanyloxy)-7-chloro-[1,4]oxazocane-4-carbonyl]-4-(2-oxo-4,5-diphenyl-oxazol-3-yl)-butyl]-amide

Synonyms:2-Trimethylsilanyl-ethanesulfonic acid [(S)-1-[(3S,6R,7S)-3-(4-benzyloxy-benzyl)-6-(tert-butyl-dimethyl-silanyloxy)-7-chloro-[1,4]oxazocane-4-carbonyl]-4-(2-oxo-4,5-diphenyl-oxazol-3-yl)-butyl]-amide

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Chemical Property of 2-Trimethylsilanyl-ethanesulfonic acid [(S)-1-[(3S,6R,7S)-3-(4-benzyloxy-benzyl)-6-(tert-butyl-dimethyl-silanyloxy)-7-chloro-[1,4]oxazocane-4-carbonyl]-4-(2-oxo-4,5-diphenyl-oxazol-3-yl)-butyl]-amide

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Technology Process of 2-Trimethylsilanyl-ethanesulfonic acid [(S)-1-[(3S,6R,7S)-3-(4-benzyloxy-benzyl)-6-(tert-butyl-dimethyl-silanyloxy)-7-chloro-[1,4]oxazocane-4-carbonyl]-4-(2-oxo-4,5-diphenyl-oxazol-3-yl)-butyl]-amide

There total 14 articles about 2-Trimethylsilanyl-ethanesulfonic acid [(S)-1-[(3S,6R,7S)-3-(4-benzyloxy-benzyl)-6-(tert-butyl-dimethyl-silanyloxy)-7-chloro-[1,4]oxazocane-4-carbonyl]-4-(2-oxo-4,5-diphenyl-oxazol-3-yl)-butyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 183794-32-3
(2S,6R,7R)-2-(4-Benzyloxy-benzyl)-7-(tert-butyl-dimethyl-silanyloxy)-4-oxa-1-aza-bicyclo[4.2.0]octane

: 183794-36-7
(S)-5-(2-Oxo-4,5-diphenyl-oxazol-3-yl)-2-(2-trimethylsilanyl-ethanesulfonylamino)-pentanoic acid

: 183794-37-8
2-Trimethylsilanyl-ethanesulfonic acid [(S)-1-[(3S,6R,7S)-3-(4-benzyloxy-benzyl)-6-(tert-butyl-dimethyl-silanyloxy)-7-chloro-[1,4]oxazocane-4-carbonyl]-4-(2-oxo-4,5-diphenyl-oxazol-3-yl)-butyl]-amide

Guidance literature:: With phosphorus pentachloride; In tetrahydrofuran; at 0 ℃; for 1.75h;
DOI:10.1021/jo961114p

Reference yield:

: 21240-34-6
4,5-diphenyl-1,3-dioxol-2-one

: 183794-37-8
2-Trimethylsilanyl-ethanesulfonic acid [(S)-1-[(3S,6R,7S)-3-(4-benzyloxy-benzyl)-6-(tert-butyl-dimethyl-silanyloxy)-7-chloro-[1,4]oxazocane-4-carbonyl]-4-(2-oxo-4,5-diphenyl-oxazol-3-yl)-butyl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Me₄NOH / 1.) MeOH, EtOH, 2.) DMF, 3 h

2: 93 percent / SOCl₂ / 23 h / Ambient temperature

3: 84 percent / triethylamine / dimethylformamide / 2.5 h / 0 °C

4: 97 percent / aq. LiOH / tetrahydrofuran / 2.5 h / Ambient temperature

5: 66 percent / PCl₅ / tetrahydrofuran / 1.75 h / 0 °C

With lithium hydroxide; thionyl chloride; phosphorus pentachloride; tetramethyl ammoniumhydroxide; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo961114p

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 183794-37-8
2-Trimethylsilanyl-ethanesulfonic acid [(S)-1-[(3S,6R,7S)-3-(4-benzyloxy-benzyl)-6-(tert-butyl-dimethyl-silanyloxy)-7-chloro-[1,4]oxazocane-4-carbonyl]-4-(2-oxo-4,5-diphenyl-oxazol-3-yl)-butyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / collidine / CH₂Cl₂ / 1.25 h

2: 79 percent / triethylamine / acetonitrile / 10 h / Heating

3: 66 percent / PCl₅ / tetrahydrofuran / 1.75 h / 0 °C

With 2,3,5-trimethyl-pyridine; phosphorus pentachloride; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo961114p