(E)-2-phenethyl-1-[chloro(p-tolylsulfinyl)methylidene]cyclobutane

Base Information

• Chemical Name: (E)-2-phenethyl-1-[chloro(p-tolylsulfinyl)methylidene]cyclobutane
• CAS No.: 1150277-26-1
• Molecular Formula: C₂₀H₂₁ClOS
• Molecular Weight: 344.905
• Mol file: 1150277-26-1.mol

Synonyms:(E)-2-phenethyl-1-[chloro(p-tolylsulfinyl)methylidene]cyclobutane

Chemical Property of (E)-2-phenethyl-1-[chloro(p-tolylsulfinyl)methylidene]cyclobutane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-phenethyl-1-[chloro(p-tolylsulfinyl)methylidene]cyclobutane

There total 1 articles about (E)-2-phenethyl-1-[chloro(p-tolylsulfinyl)methylidene]cyclobutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloromethyl p-tolyl sulfoxide (24824-93-9) + 2-(2-phenylethyl)cyclobutanone (106988-12-9) → (E)-2-phenethyl-1-[chloro(p-tolylsulfinyl)methylidene]cyclobutane (1150277-26-1) + (Z)-2-phenethyl-1-[chloro(p-tolylsulfinyl)methylidene]cyclobutane (1150277-31-8)

Guidance literature:

optical yield given as %de;

DOI:10.1016/j.tetlet.2009.02.053

Reference yield: 74.0%

acetic acid tert-butyl ester (540-88-5) + (E)-2-phenethyl-1-[chloro(p-tolylsulfinyl)methylidene]cyclobutane (1150277-26-1) → tert-butyl (1-[chloro(p-tolylsulfinyl)methyl]-2-phenethylcyclobutyl)acetate

Guidance literature:

acetic acid tert-butyl ester; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.166667h; Inert atmosphere;

(E)-2-phenethyl-1-[chloro(p-tolylsulfinyl)methylidene]cyclobutane; In tetrahydrofuran; at -78 ℃; for 0.25h; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; water; stereospecific reaction;

DOI:10.1016/j.tet.2010.12.023

Reference yield: 74.0%

(E)-2-phenethyl-1-[chloro(p-tolylsulfinyl)methylidene]cyclobutane (1150277-26-1) + t-butyl lithioacetate (150942-98-6) → C26H33ClO3S

Guidance literature:

In tetrahydrofuran; at -78 ℃;

DOI:10.1016/j.tetlet.2009.02.053

upstream raw materials:

chloromethyl p-tolyl sulfoxide

2-(2-phenylethyl)cyclobutanone

Downstream raw materials:

tert-butyl (5-phenethylcyclopent-1-enyl)acetate