(3R,4S,5S)-diisopropyl (1,5-dimethyl-2-oxo-4-phenylpyrrolidin-3-yl)phosphonate

Base Information

Chemical Name:(3R,4S,5S)-diisopropyl (1,5-dimethyl-2-oxo-4-phenylpyrrolidin-3-yl)phosphonate
CAS No.:950782-94-2
Molecular Formula:C₁₈H₂₈NO₄P
Molecular Weight:353.398
Hs Code.:

Synonyms:(3R,4S,5S)-diisopropyl (1,5-dimethyl-2-oxo-4-phenylpyrrolidin-3-yl)phosphonate

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Chemical Property of (3R,4S,5S)-diisopropyl (1,5-dimethyl-2-oxo-4-phenylpyrrolidin-3-yl)phosphonate

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Technology Process of (3R,4S,5S)-diisopropyl (1,5-dimethyl-2-oxo-4-phenylpyrrolidin-3-yl)phosphonate

There total 1 articles about (3R,4S,5S)-diisopropyl (1,5-dimethyl-2-oxo-4-phenylpyrrolidin-3-yl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 24074-26-8
ethyl (diisopropylphosphoryl)acetate

: 161511-56-4,823785-72-4
N-methyl-(4S)-methyl-(5R)-phenyl-1,2,3-oxathiazolidine S,S-dioxide

: 950782-94-2
(3R,4S,5S)-diisopropyl (1,5-dimethyl-2-oxo-4-phenylpyrrolidin-3-yl)phosphonate

Guidance literature:: ethyl (diisopropylphosphoryl)acetate; With potassium tert-butylate; In 1,4-dioxane; at 20 ℃; for 0.5h;

N-methyl-(4S)-methyl-(5R)-phenyl-1,2,3-oxathiazolidine S,S-dioxide; In 1,4-dioxane; for 18h; Heating;

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 3h; Further stages.;
DOI:10.1039/b706315f

Reference yield: 73.0%

: 950782-94-2
(3R,4S,5S)-diisopropyl (1,5-dimethyl-2-oxo-4-phenylpyrrolidin-3-yl)phosphonate

: (S)-3-hydroxy-1,5-dimethyl-4-phenyl-1,5-dihydropyrrol-2-one

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃; for 4h;
DOI:10.1039/b706315f

Reference yield: 56.0%

: 950782-94-2
(3R,4S,5S)-diisopropyl (1,5-dimethyl-2-oxo-4-phenylpyrrolidin-3-yl)phosphonate

: 75-07-0,9002-91-9
acetaldehyde

: (3Z)-(4R,5S)-ethylidene-1,5-dimethyl-4-phenyl-pyrrolidin-2-one

: (3E)-(4R,5S)-ethylidene-1,5-dimethyl-4-phenyl-pyrrolidin-2-one

: (S)-3-hydroxy-1,5-dimethyl-4-phenyl-1,5-dihydropyrrol-2-one

Guidance literature:: (3R,4S,5S)-diisopropyl (1,5-dimethyl-2-oxo-4-phenylpyrrolidin-3-yl)phosphonate; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.25h;

acetaldehyde; In tetrahydrofuran; at 20 ℃; for 5.5h; Further stages.;
DOI:10.1039/b706315f