5-HYDRAZINO-2-METHOXYPYRIDINE

Base Information

• Chemical Name: 5-HYDRAZINO-2-METHOXYPYRIDINE
• CAS No.: 160664-95-9
• Molecular Formula: C6H9N3O
• Molecular Weight: 139.157
• Hs Code.: 2933990090
• Mol file: 160664-95-9.mol

Synonyms:Pyridine,5-hydrazino-2-methoxy- (9CI);5-Hydrazino-2-methoxypyridine;

Chemical Property of 5-HYDRAZINO-2-METHOXYPYRIDINE

Chemical Property:

• Vapor Pressure: 0.003mmHg at 25°C
• Melting Point: 64 °C
• Refractive Index: 1.615
• Boiling Point: 283.526 °C at 760 mmHg
• PKA: 4.60±0.24(Predicted)
• Flash Point: 125.272 °C
• PSA: 60.17000
• Density: 1.228 g/cm³
• LogP: 1.14910
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

(6-Methoxy-pyridin-3-yl)-hydrazine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-HYDRAZINO-2-METHOXYPYRIDINE

There total 4 articles about 5-HYDRAZINO-2-METHOXYPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

6-methoxy-pyridin-3-ylamine (6628-77-9) → 5-hydrazinyl-2-methoxy pyridine (160664-95-9)

Guidance literature:

6-methoxy-pyridin-3-ylamine; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.5h;

With hydrogenchloride; tin(II) chloride dihdyrate; In water; at 0 ℃; for 2.5h;

With potassium hydroxide; In water;

DOI:10.1021/ol902139r

Reference yield: 60.0%

5-hydrazinyl-2-methoxypyridine hydrochloride (179543-88-5,524699-82-9) → 5-hydrazinyl-2-methoxy pyridine (160664-95-9)

Guidance literature:

5-hydrazinyl-2-methoxypyridine hydrochloride; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 1.83333h;

With hydrogenchloride; tin(ll) chloride; In water; at 10 - 20 ℃; for 13.5h;

With sodium hydroxide; In chloroform; water; at 0 ℃; Product distribution / selectivity;

Reference yield:

tin(II)chloride dihydrate + 6-methoxy-pyridin-3-ylamine (6628-77-9) → 5-hydrazinyl-2-methoxy pyridine (160664-95-9)

Guidance literature:

With sodium hydroxide; sodium nitrite; In hydrogenchloride; water; ethyl acetate;

upstream raw materials:

6-methoxy-pyridin-3-ylamine

5-hydrazinyl-2-methoxypyridine hydrochloride

Downstream raw materials:

5-(4-chlorophenyl)-1-(6-methoxy-3-pyridyl)pyrazole-3-carboxylic acid ethyl ester

S29434

1-(6-methoxy-3-pyridyl)-5-(3-methylphenyl)pyrazole-3-carboxylic acid ethyl ester

5-(4-Methoxyphenyl)-1-(6-methoxy-pyridin-3-yl)pyrazole-3-carboxylic acid ethyl ester