Technology Process of S29434
There total 14 articles about S29434 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); potassium acetate;
In
N,N-dimethyl acetamide;
at 150 ℃;
for 4h;
Inert atmosphere;
DOI:10.1124/mol.118.114231
- Guidance literature:
-
2-furanoic acid;
With
N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
N,N-dimethyl-formamide;
at 0 ℃;
for 0.25h;
C16H16N4O;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 2h;
DOI:10.1124/mol.118.114231
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium diisopropyl amide; n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere
1.2: 1 h / -78 °C / Inert atmosphere
2.1: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C
3.1: phosphorus tribromide / dichloromethane / 0.5 h / 0 - 20 °C
4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
4.2: 4 h / 20 °C / Inert atmosphere
5.1: tetrakis(triphenylphosphine) palladium(0); potassium acetate / N,N-dimethyl acetamide / 4 h / 150 °C / Inert atmosphere
With
sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium(0); n-butyllithium; potassium acetate; phosphorus tribromide; sodium hydride; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1124/mol.118.114231
