C₁₇H₁₈FN₅

Base Information

• Chemical Name: C₁₇H₁₈FN₅
• CAS No.: 1431626-87-7
• Molecular Formula: C₁₇H₁₈FN₅
• Molecular Weight: 311.362
• Mol file: 1431626-87-7.mol

Synonyms:C₁₇H₁₈FN₅

Chemical Property of C₁₇H₁₈FN₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₇H₁₈FN₅

There total 6 articles about C₁₇H₁₈FN₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

4-aminopiperidine (13035-19-3) + C12H7ClFN3 (1431626-84-4) → C17H18FN5 (1431626-87-7)

Guidance literature:

With triethylamine; In ethanol; water; at 20 ℃; for 16h; Reflux;

DOI:10.1016/j.tetlet.2013.03.015

Reference yield:

2-fluoro-3-oxo-3-phenylpropanenitrile → C17H18FN5 (1431626-87-7)

Guidance literature:

Multi-step reaction with 6 steps

1: hydrazine hydrate / ethanol / Reflux

2: acetic acid / 10 h / 100 °C

3: sodium hydroxide / diethyl ether; water / 3 h / 85 °C

4: diphenylether; biphenyl / 5 h / 230 °C

5: trichlorophosphate / 4 h / Reflux

6: triethylamine / ethanol; water / 16 h / 20 °C / Reflux

With hydrazine hydrate; acetic acid; triethylamine; sodium hydroxide; trichlorophosphate; In diphenylether; biphenyl; diethyl ether; ethanol; water;

DOI:10.1016/j.tetlet.2013.03.015

Reference yield:

benzoyl chloride (98-88-4) → C17H18FN5 (1431626-87-7)

Guidance literature:

Multi-step reaction with 7 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 5 h / -78 °C / Inert atmosphere

2: hydrazine hydrate / ethanol / Reflux

3: acetic acid / 10 h / 100 °C

4: sodium hydroxide / diethyl ether; water / 3 h / 85 °C

5: diphenylether; biphenyl / 5 h / 230 °C

6: trichlorophosphate / 4 h / Reflux

7: triethylamine / ethanol; water / 16 h / 20 °C / Reflux

With hydrazine hydrate; acetic acid; triethylamine; sodium hydroxide; lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran; diphenylether; biphenyl; diethyl ether; ethanol; water;

DOI:10.1016/j.tetlet.2013.03.015

upstream raw materials:

benzoyl chloride

4-aminopiperidine

C₁₂H₇ClFN₃

3-amino-4-fluoro-5-phenyl-1H-pyrazole