1-[1-diethylamino-1-phenylmeth-(E)-ylidene]-3-(4-methylbenzoyl)thiourea

Base Information

• Chemical Name: 1-[1-diethylamino-1-phenylmeth-(E)-ylidene]-3-(4-methylbenzoyl)thiourea
• CAS No.: 952612-56-5
• Molecular Formula: C₂₀H₂₃N₃OS
• Molecular Weight: 353.488

Synonyms:1-[1-diethylamino-1-phenylmeth-(E)-ylidene]-3-(4-methylbenzoyl)thiourea

Chemical Property of 1-[1-diethylamino-1-phenylmeth-(E)-ylidene]-3-(4-methylbenzoyl)thiourea

Chemical Property:

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Technology Process of 1-[1-diethylamino-1-phenylmeth-(E)-ylidene]-3-(4-methylbenzoyl)thiourea

There total 2 articles about 1-[1-diethylamino-1-phenylmeth-(E)-ylidene]-3-(4-methylbenzoyl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

N,N-diethylbenzamidine (50458-37-2) + 4-methylbenzoyl isothiocyanate (16794-68-6) → 1-[1-diethylamino-1-phenylmeth-(E)-ylidene]-3-(4-methylbenzoyl)thiourea (952612-56-5)

Guidance literature:

In toluene; at -5 - 20 ℃; for 3h;

DOI:10.1016/j.ejmech.2013.03.020

Reference yield:

benzonitrile (100-47-0) → 1-[1-diethylamino-1-phenylmeth-(E)-ylidene]-3-(4-methylbenzoyl)thiourea (952612-56-5)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum (III) chloride / 0 - 30 °C

2: toluene / 3 h / -5 - 20 °C

With aluminum (III) chloride; In toluene;

DOI:10.1016/j.ejmech.2013.03.020

Reference yield: 56.0%

1-[1-diethylamino-1-phenylmeth-(E)-ylidene]-3-(4-methylbenzoyl)thiourea (952612-56-5) + 2-chloromethyl-5,6-dimethyl-thieno[2,3-d]pyrimidin-4-ylamine (877964-04-0) → N-[5-(4-amino-5,6-dimethylthieno[2,3-d]pyrimidin-2-yl)-4-phenylthiazol-2-yl]-4-methylbenzamide (1443221-48-4)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 48h;

DOI:10.1016/j.ejmech.2013.03.020

upstream raw materials:

N,N-diethylbenzamidine

4-methylbenzoyl isothiocyanate

benzonitrile

Downstream raw materials:

N-[5-(4-amino-5,6,7,8-tetrahydrobenzo[4,5]-thieno[2,3-d]pyrimidin-2-yl)-4-phenylthiazol-2-yl]-4-methylbenzamide

N-[5-(4-amino-5,6-dimethylthieno[2,3-d]pyrimidin-2-yl)-4-phenylthiazol-2-yl]-4-methylbenzamide

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