benzyl (4S,7S)-4-(2-(4-bromophenyl)-2-oxoethylcarbamoyl)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamate

Base Information

Chemical Name:benzyl (4S,7S)-4-(2-(4-bromophenyl)-2-oxoethylcarbamoyl)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamate
CAS No.:1430061-61-2
Molecular Formula:C₂₆H₂₇BrN₄O₆
Molecular Weight:571.428
Hs Code.:

Synonyms:benzyl (4S,7S)-4-(2-(4-bromophenyl)-2-oxoethylcarbamoyl)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamate

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Chemical Property of benzyl (4S,7S)-4-(2-(4-bromophenyl)-2-oxoethylcarbamoyl)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamate

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Technology Process of benzyl (4S,7S)-4-(2-(4-bromophenyl)-2-oxoethylcarbamoyl)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamate

There total 4 articles about benzyl (4S,7S)-4-(2-(4-bromophenyl)-2-oxoethylcarbamoyl)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.8%

: 174799-32-7
(1S,9S)-9-(benzyloxycarbonylamino)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid

: 5467-72-1
α-amino-4-bromoacetophenone hydrochloride

: 1430061-61-2
benzyl (4S,7S)-4-(2-(4-bromophenyl)-2-oxoethylcarbamoyl)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 106928-72-7
(1S,9S)-t-butyl 1,2,3,4,7,8,9,10-octahydro-6,10-dioxo-9-phthalimidopyridazino<1,2-a><1,2>diazepine-1-carboxylate

: 1430061-61-2
benzyl (4S,7S)-4-(2-(4-bromophenyl)-2-oxoethylcarbamoyl)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine / ethanol / 3 h / 20 °C

2: sodium carbonate / N,N-dimethyl-formamide / 6 h / 0 - 20 °C

3: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

4: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; hydrazine; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 88767-96-8
(1S,9S)-t-butyl 9-amino-octahydro-6,10-dioxo-6H-pyridazino<1,2-a><1,2>diazepine-1-carboxylate

: 1430061-61-2
benzyl (4S,7S)-4-(2-(4-bromophenyl)-2-oxoethylcarbamoyl)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / N,N-dimethyl-formamide / 6 h / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

3: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;