benzyl (4S,7S)-4-(5-(4-bromophenyl)-1H-imidazol-2-yl)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamate

Base Information

Chemical Name:benzyl (4S,7S)-4-(5-(4-bromophenyl)-1H-imidazol-2-yl)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamate
CAS No.:1430061-52-1
Molecular Formula:C₂₆H₂₆BrN₅O₄
Molecular Weight:552.428
Hs Code.:

Synonyms:benzyl (4S,7S)-4-(5-(4-bromophenyl)-1H-imidazol-2-yl)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamate

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Chemical Property of benzyl (4S,7S)-4-(5-(4-bromophenyl)-1H-imidazol-2-yl)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamate

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Technology Process of benzyl (4S,7S)-4-(5-(4-bromophenyl)-1H-imidazol-2-yl)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamate

There total 5 articles about benzyl (4S,7S)-4-(5-(4-bromophenyl)-1H-imidazol-2-yl)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.1%

: 1430061-61-2
benzyl (4S,7S)-4-(2-(4-bromophenyl)-2-oxoethylcarbamoyl)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamate

: 1430061-52-1
benzyl (4S,7S)-4-(5-(4-bromophenyl)-1H-imidazol-2-yl)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamate

Guidance literature:: With ammonium acetate; In 1,4-dioxane; at 110 ℃; for 12h; Sealed tube;

Reference yield:

: 106928-72-7
(1S,9S)-t-butyl 1,2,3,4,7,8,9,10-octahydro-6,10-dioxo-9-phthalimidopyridazino<1,2-a><1,2>diazepine-1-carboxylate

: 1430061-52-1
benzyl (4S,7S)-4-(5-(4-bromophenyl)-1H-imidazol-2-yl)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrazine / ethanol / 3 h / 20 °C

2: sodium carbonate / N,N-dimethyl-formamide / 6 h / 0 - 20 °C

3: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

4: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

5: ammonium acetate / 1,4-dioxane / 12 h / 110 °C / Sealed tube

With ammonium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; hydrazine; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 88767-96-8
(1S,9S)-t-butyl 9-amino-octahydro-6,10-dioxo-6H-pyridazino<1,2-a><1,2>diazepine-1-carboxylate

: 1430061-52-1
benzyl (4S,7S)-4-(5-(4-bromophenyl)-1H-imidazol-2-yl)-6,10-dioxooctahydro-1H-pyridazino[1,2-a][1,2]diazepin-7-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / N,N-dimethyl-formamide / 6 h / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

3: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

4: ammonium acetate / 1,4-dioxane / 12 h / 110 °C / Sealed tube

With ammonium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;