4-[4-[(3,3-dimethylpiperazin-1-yl)methyl]-3-(trifluoromethoxy)phenyl]morpholine

Base Information

Chemical Name:4-[4-[(3,3-dimethylpiperazin-1-yl)methyl]-3-(trifluoromethoxy)phenyl]morpholine
CAS No.:1460030-92-5
Molecular Formula:C₁₈H₂₆F₃N₃O₂
Molecular Weight:373.419
Hs Code.:

Synonyms:4-[4-[(3,3-dimethylpiperazin-1-yl)methyl]-3-(trifluoromethoxy)phenyl]morpholine

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Chemical Property of 4-[4-[(3,3-dimethylpiperazin-1-yl)methyl]-3-(trifluoromethoxy)phenyl]morpholine

Chemical Property:

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Technology Process of 4-[4-[(3,3-dimethylpiperazin-1-yl)methyl]-3-(trifluoromethoxy)phenyl]morpholine

There total 4 articles about 4-[4-[(3,3-dimethylpiperazin-1-yl)methyl]-3-(trifluoromethoxy)phenyl]morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1460030-87-8
tert-butyl 2,2-dimethyl-4-[[4-(morpholin-4-yl)-2-(trifluoromethoxy)phenyl]methyl]piperazine-1-carboxylate

: 1460030-92-5
4-[4-[(3,3-dimethylpiperazin-1-yl)methyl]-3-(trifluoromethoxy)phenyl]morpholine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 3h;

Reference yield:

: 220996-80-5
4-bromo-2-[(trifluoromethyl)oxy]benzaldehyde

: 1460030-92-5
4-[4-[(3,3-dimethylpiperazin-1-yl)methyl]-3-(trifluoromethoxy)phenyl]morpholine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 15 h / 75 °C / Inert atmosphere

2.1: 1,2-dichloro-ethane / 1 h / 20 °C

2.2: 15 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic acid; sodium t-butanolate; In dichloromethane; 1,2-dichloro-ethane; toluene;

Reference yield:

: 674792-07-5
2,2-dimethyl-piperazine-1-carboxylic acid tert-butyl ester

: 1460030-92-5
4-[4-[(3,3-dimethylpiperazin-1-yl)methyl]-3-(trifluoromethoxy)phenyl]morpholine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,2-dichloro-ethane / 1 h / 20 °C

1.2: 15 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

With trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane;