N-(5-chloro-2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-(3-chloropropanamido)benzamide

Base Information

Chemical Name:N-(5-chloro-2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-(3-chloropropanamido)benzamide
CAS No.:1429294-66-5
Molecular Formula:C₂₉H₃₀Cl₂N₆O₂
Molecular Weight:565.502
Hs Code.:

Synonyms:N-(5-chloro-2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-(3-chloropropanamido)benzamide

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Chemical Property of N-(5-chloro-2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-(3-chloropropanamido)benzamide

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Technology Process of N-(5-chloro-2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-(3-chloropropanamido)benzamide

There total 12 articles about N-(5-chloro-2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-(3-chloropropanamido)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1429294-63-2
4-amino-N-(5-chloro-2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)benzamide

: 625-36-5
2-chloropropionyl chloride

: 1429294-66-5
N-(5-chloro-2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-(3-chloropropanamido)benzamide

Guidance literature:: In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.ejmech.2013.01.051

Reference yield:

: 41995-04-4
4-chloro-2-nitro-benzoyl chloride

: 1429294-66-5
N-(5-chloro-2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-(3-chloropropanamido)benzamide

Guidance literature:: Multi-step reaction with 8 steps

1: triethylamine / chloroform / 5 h / 20 °C

2: potassium hydroxide / ethanol / 2 h / Reflux

3: N,N-diethylaniline; trichlorophosphate / toluene / 6 h / 80 °C

4: tetrahydrofuran / 5 h / Reflux

5: hydrogenchloride; tin(II) chloride dihdyrate / ethanol; water / 5 h / Reflux

6: dichloromethane / 5 h / 0 - 20 °C

7: hydrogenchloride; tin(II) chloride dihdyrate / ethanol; water / 5 h / Reflux

8: dichloromethane / 0 - 20 °C

With hydrogenchloride; tin(II) chloride dihdyrate; triethylamine; N,N-diethylaniline; potassium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; toluene;
DOI:10.1016/j.ejmech.2013.01.051

Reference yield:

: 6280-88-2
4-chloro-2-nitro-benzoic acid

: 1429294-66-5
N-(5-chloro-2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-(3-chloropropanamido)benzamide

Guidance literature:: Multi-step reaction with 9 steps

1: thionyl chloride / 1.5 h / 80 °C

2: triethylamine / chloroform / 5 h / 20 °C

3: potassium hydroxide / ethanol / 2 h / Reflux

4: N,N-diethylaniline; trichlorophosphate / toluene / 6 h / 80 °C

5: tetrahydrofuran / 5 h / Reflux

6: hydrogenchloride; tin(II) chloride dihdyrate / ethanol; water / 5 h / Reflux

7: dichloromethane / 5 h / 0 - 20 °C

8: hydrogenchloride; tin(II) chloride dihdyrate / ethanol; water / 5 h / Reflux

9: dichloromethane / 0 - 20 °C

With hydrogenchloride; thionyl chloride; tin(II) chloride dihdyrate; triethylamine; N,N-diethylaniline; potassium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; toluene;
DOI:10.1016/j.ejmech.2013.01.051