1429294-63-2

Upstream product

• 62-23-7 4-nitro-benzoic acid 
• 1429294-61-0 N-(5-chloro-2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-nitrobenzamide 
• 1266584-24-0 N¹-(2-(2-amino-4-chlorophenyl)quinazolin-4-yl)-N³,N³-dimethylpropane-1,3-diamine 
• 1266584-22-8 N¹-(2-(4-chloro-2-nitrophenyl)quinazolin-4-yl)-N³,N³-dimethylpropane-1,3-diamine 
• 1266584-21-7 4-chloro-2-(4-chloro-2-nitrophenyl)quinazoline 
• 34576-17-5 2-(4-chloro-2-nitrophenyl)-3H-quinazolin-4-one 
• 349135-17-7 N-(2-carbamoylphenyl)-4-chloro-2-nitrobenzamide 
• 122-04-3 4-nitro-benzoyl chloride 
• 28144-70-9 anthranilic acid amide 
• 6280-88-2 4-chloro-2-nitro-benzoic acid 
• 41995-04-4 4-chloro-2-nitro-benzoyl chloride 

Downstream Products

• 1429294-53-0 N-(5-chloro-2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-(3-(diethylamino)propanamido)benzamide 
• 1429294-54-1 N-(5-chloro-2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-(3-(pyrrolidin-1-yl)propanamido)benzamide 
• 1429294-55-2 N-(5-chloro-2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-(3-morpholinopropanamido)benzamide 
• 1429294-56-3 N-(5-chloro-2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-(3-(4-methylpiperazin-1-yl)propanamido)benzamide 
• 1429294-57-4 N-(5-chloro-2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-(3-((3-(dimethylamino)propyl)amino)propanamido)benzamide 
• 1429294-66-5 N-(5-chloro-2-(4-((3-(dimethylamino)propyl)amino)quinazolin-2-yl)phenyl)-4-(3-chloropropanamido)benzamide 

Relevant academic research and scientific papers

New quinazoline derivatives for telomeric G-quadruplex DNA: Effects of an added phenyl group on quadruplex binding ability

To improve the selectivity of indoloquinoline or benzofuroquinoline derivatives, we previously reported several quinazoline derivatives [17]. These compounds could mimic a tetracyclic aromatic system through intramolecular hydrogen bond. Studies showed that these quinazoline derivatives were effective and selective telomeric G-quadruplex ligands. With this encouragement, here we synthesized a series of N-(2-(quinazolin-2-yl)phenyl)benzamide (QPB) compounds as modified quinazoline derivatives. In this modification, a phenyl group was introduced to the aromatic core. The evaluation results showed that part of QPB derivatives had stronger binding ability and better selectivity for telomeric G-quadruplex DNA than LZ-11, the most potential compound of reported quinazoline derivatives. Furthermore, telomerase inhibition of QPB derivatives and their cellular effects were studied.