1,3-Bis(4-fluorobenzoyl)benzene

Base Information

• Chemical Name: 1,3-Bis(4-fluorobenzoyl)benzene
• CAS No.: 108464-88-6
• Molecular Formula: C20H12F2O2
• Molecular Weight: 322.311
• Hs Code.: 2914700090
• DSSTox Substance ID: DTXSID20350852
• Nikkaji Number: J627.144H
• Wikidata: Q72445806
• Mol file: 108464-88-6.mol

Synonyms:1,3-Bis(4-fluorobenzoyl)benzene;108464-88-6;1,3-Phenylenebis((4-fluorophenyl)methanone);[3-(4-fluorobenzoyl)phenyl]-(4-fluorophenyl)methanone;Methanone, 1,3-phenylenebis[(4-fluorophenyl)-;C20H12F2O2;SCHEMBL209624;DTXSID20350852;PISLKPDKKIDMQT-UHFFFAOYSA-N;1,3-bis-(4-fluorobenzoyl)benzene;AMY38283;1,3-bis-(4-fluorobenzoyl) benzene;1,3-?Bis(4-?fluorobenzoyl)?benzene;AKOS015895843;1,3-Bis(4-fluorobenzoyl)benzene, 98%;AS-78647;CS-0325300;FT-0654788;E78127;A801881;J-002148;[3-(4-fluorobenzoyl)phenyl](4-fluorophenyl)methanone

Chemical Property of 1,3-Bis(4-fluorobenzoyl)benzene

Chemical Property:

• Vapor Pressure: 3.08E-09mmHg at 25°C
• Melting Point: 181-183 °C(lit.)
• Refractive Index: 1.59
• Boiling Point: 476.3 °C at 760 mmHg
• Flash Point: 178.9 °C
• PSA: 34.14000
• Density: 1.268 g/cm³
• LogP: 4.42680
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 322.08053595
• Heavy Atom Count: 24
• Complexity: 409

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,3-Bis(4-fluorobenzoyl)benzene 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)C(=O)C2=CC=C(C=C2)F)C(=O)C3=CC=C(C=C3)F
• Uses: 1,3-Bis(4-fluorobenzoyl)benzene was used for the synthesis of sulfonated poly(aryl ether ketone)s (SPAEK) copolymers by aromatic nucleophilic polycondensation. It may be employed as an activated nonsulfonated difluoro-monomer for the synthesis of fluorenyl-containing sulfonated poly(aryl ether ether ketone ketone)s.

Technology Process of 1,3-Bis(4-fluorobenzoyl)benzene

There total 2 articles about 1,3-Bis(4-fluorobenzoyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

fluorobenzene (462-06-6) + benzene-1,3-dicarbonyl dichloride (99-63-8) → 1,3-bis(4'-fluorobenzoyl)benzene (108464-88-6)

Guidance literature:

With aluminium trichloride; at 23 ℃; for 4h;

DOI:10.1021/ol052587y

Reference yield: 76.0%

tris(4-fluorophenyl)bismuthane (437-29-6) + benzene-1,3-dicarbonyl dichloride (99-63-8) → 1,3-bis(4'-fluorobenzoyl)benzene (108464-88-6)

Guidance literature:

With triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 80 ℃; for 3h;

DOI:10.1016/j.tet.2007.10.047

Reference yield: 87.3%

1,3-bis(4'-fluorobenzoyl)benzene (108464-88-6) → 1,3-bis(3-nitro-4-fluorobenzoyl)benzene

Guidance literature:

With sulfuric acid; nitric acid; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate;

upstream raw materials:

fluorobenzene

benzene-1,3-dicarbonyl dichloride

tris(4-fluorophenyl)bismuthane

Downstream raw materials:

1,3-di-(3-p-fluorophenyl-[3H]-naphtho[2,1-b]pyran-3-yl)-benzene

1,3-di-(8-bromo-3-p-fluorophenyl-[3H]-naphtho[2,1-b]pyran-3-yl)-benzene

1,3-di-(2-p-fluorophenyl-6-phenyl-5-ethoxycarbonyl-[2H]-naphtho[2,1-b]pyran-2-yl)-benzene

1,3-bis[4-(3-aminophenoxy)benzoyl]benzene

Refernces

• 1、 Parker, Erica N.,Song, Jiangli,Kishore Kumar,Odutola, Samuel O.,Chavarria, Gustavo E.,Charlton-Sevcik, Amanda K.,Strecker, Tracy E.,Barnes, Ashleigh L.,Sudhan, Dhivya R.,Wittenborn, Thomas R.,Siemann, Dietmar W.,Horsman, Michael R.,Chaplin, David J.,Trawick, Mary Lynn,Pinney, Kevin G.. "Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L". . p. 6974 - 6992. Retrieved 2015/11/11.
• 2、 Zhao, Hong,Yin, Lin,Cai, Mingzhong. "A phosphane-free, atom-efficient cross-coupling reaction of triarylbismuths with acyl chlorides catalyzed by MCM-41-immobilized palladium complex". . p. 1337 - 1345. Retrieved 2013/04/10.