2'-C-methyl-3'-O-propionyluridine 5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)-thiophosphoramidate

Base Information

Chemical Name:2'-C-methyl-3'-O-propionyluridine 5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)-thiophosphoramidate
CAS No.:1365635-03-5
Molecular Formula:C₂₅H₃₄N₃O₁₀PS
Molecular Weight:599.599
Hs Code.:

Synonyms:2'-C-methyl-3'-O-propionyluridine 5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)-thiophosphoramidate

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Chemical Property of 2'-C-methyl-3'-O-propionyluridine 5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)-thiophosphoramidate

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Technology Process of 2'-C-methyl-3'-O-propionyluridine 5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)-thiophosphoramidate

There total 3 articles about 2'-C-methyl-3'-O-propionyluridine 5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)-thiophosphoramidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1365634-48-5
2'-C-methyluridine 5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate

: 123-62-6
propionic acid anhydride

: 1365635-03-5
2'-C-methyl-3'-O-propionyluridine 5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)-thiophosphoramidate

Guidance literature:: With pyridine; at 20 - 40 ℃;

Reference yield:

: 1365634-46-3
2'-methyluridine

: 1365635-03-5
2'-C-methyl-3'-O-propionyluridine 5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)-thiophosphoramidate

Guidance literature:: Multi-step reaction with 3 steps

1: 1-methyl-1H-imidazole / acetonitrile / 2 h / 70 °C

2: water; formic acid / 1.5 h / 50 °C

3: pyridine / 20 - 40 °C

With pyridine; 1-methyl-1H-imidazole; formic acid; water; In acetonitrile;

Reference yield:

: 1365634-47-4
2'-methyluridine

: 1365635-03-5
2'-C-methyl-3'-O-propionyluridine 5'-(O-phenyl-N-(S)-1-(isopropoxycarbonyl)ethyl)-thiophosphoramidate

Guidance literature:: Multi-step reaction with 2 steps

1: water; formic acid / 1.5 h / 50 °C

2: pyridine / 20 - 40 °C

With pyridine; formic acid; water;