ethyl 9-(4'-chlorophenyl)-7-methyl-2-(3'-amino-4'-(4''-chlorophenyl)-5'-ethoxycarbonyl-6'-methylthieno[2,3-b]pyridin-2'-yl)-4-oxo-3,4-dihydropyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carboxylate

Base Information

Chemical Name:ethyl 9-(4'-chlorophenyl)-7-methyl-2-(3'-amino-4'-(4''-chlorophenyl)-5'-ethoxycarbonyl-6'-methylthieno[2,3-b]pyridin-2'-yl)-4-oxo-3,4-dihydropyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carboxylate
CAS No.:868682-52-4
Molecular Formula:C₃₆H₂₇Cl₂N₅O₅S₂
Molecular Weight:744.679
Hs Code.:

ethyl 9-(4'-chlorophenyl)-7-methyl-2-(3'-amino-4'-(4''-chlorophenyl)-5'-ethoxycarbonyl-6'-methylthieno[2,3-b]pyridin-2'-yl)-4-oxo-3,4-dihydropyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carboxylate

Synonyms:ethyl 9-(4'-chlorophenyl)-7-methyl-2-(3'-amino-4'-(4''-chlorophenyl)-5'-ethoxycarbonyl-6'-methylthieno[2,3-b]pyridin-2'-yl)-4-oxo-3,4-dihydropyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carboxylate

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Chemical Property of ethyl 9-(4'-chlorophenyl)-7-methyl-2-(3'-amino-4'-(4''-chlorophenyl)-5'-ethoxycarbonyl-6'-methylthieno[2,3-b]pyridin-2'-yl)-4-oxo-3,4-dihydropyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carboxylate

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Technology Process of ethyl 9-(4'-chlorophenyl)-7-methyl-2-(3'-amino-4'-(4''-chlorophenyl)-5'-ethoxycarbonyl-6'-methylthieno[2,3-b]pyridin-2'-yl)-4-oxo-3,4-dihydropyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carboxylate

There total 5 articles about ethyl 9-(4'-chlorophenyl)-7-methyl-2-(3'-amino-4'-(4''-chlorophenyl)-5'-ethoxycarbonyl-6'-methylthieno[2,3-b]pyridin-2'-yl)-4-oxo-3,4-dihydropyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 868682-51-3
ethyl 9-(4'-chlorophenyl)-7-methyl-2-(4'-(4''-chlorophenyl)-3'-cyano-5'-ethoxycarbonyl-6'-methylpyridin-2'-ylthiomethyl)-4-oxo-3,4-dihydropyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carboxylate

: 868682-52-4
ethyl 9-(4'-chlorophenyl)-7-methyl-2-(3'-amino-4'-(4''-chlorophenyl)-5'-ethoxycarbonyl-6'-methylthieno[2,3-b]pyridin-2'-yl)-4-oxo-3,4-dihydropyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carboxylate

Guidance literature:: With sodium ethanolate; In ethanol; for 0.0833333h; Heating;
DOI:10.1002/jhet.5570420606

Reference yield:

: 97651-28-0
ethyl 4-(4'-chlorophenyl)-3-cyano-6-methyl-1,2-dihydropyridine-5-carboxylate

: 868682-52-4
ethyl 9-(4'-chlorophenyl)-7-methyl-2-(3'-amino-4'-(4''-chlorophenyl)-5'-ethoxycarbonyl-6'-methylthieno[2,3-b]pyridin-2'-yl)-4-oxo-3,4-dihydropyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / sodium acetate trihydrate / ethanol / 3 h / Heating

2: 93 percent / sodium ethoxide / ethanol / 0.08 h / Heating

3: 87 percent / 3 h / Heating

4: 82 percent / sodium acetate trihydrate / ethanol / 3 h / Heating

5: 77 percent / sodium ethoxide / ethanol / 0.08 h / Heating

With sodium ethanolate; sodium acetate; In ethanol; 2: Thorpe-Ziegler cyclization / 5: Thorpe-Ziegler cyclization;
DOI:10.1002/jhet.5570420606

Reference yield:

: 868682-44-4
ethyl 2-chloromethyl-9-(4'-chlorophenyl)-7-methyl-4-oxo-3,4-dihydropyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carboxylate

: 868682-52-4
ethyl 9-(4'-chlorophenyl)-7-methyl-2-(3'-amino-4'-(4''-chlorophenyl)-5'-ethoxycarbonyl-6'-methylthieno[2,3-b]pyridin-2'-yl)-4-oxo-3,4-dihydropyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / sodium acetate trihydrate / ethanol / 3 h / Heating

2: 77 percent / sodium ethoxide / ethanol / 0.08 h / Heating

With sodium ethanolate; sodium acetate; In ethanol; 2: Thorpe-Ziegler cyclization;
DOI:10.1002/jhet.5570420606