ethyl 2-chloromethyl-9-(4'-chlorophenyl)-7-methyl-4-oxo-3,4-dihydropyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carboxylate

Base Information

Chemical Name:ethyl 2-chloromethyl-9-(4'-chlorophenyl)-7-methyl-4-oxo-3,4-dihydropyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carboxylate
CAS No.:868682-44-4
Molecular Formula:C₂₀H₁₅Cl₂N₃O₃S
Molecular Weight:448.329
Hs Code.:

Synonyms:ethyl 2-chloromethyl-9-(4'-chlorophenyl)-7-methyl-4-oxo-3,4-dihydropyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carboxylate

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Chemical Property of ethyl 2-chloromethyl-9-(4'-chlorophenyl)-7-methyl-4-oxo-3,4-dihydropyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carboxylate

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Technology Process of ethyl 2-chloromethyl-9-(4'-chlorophenyl)-7-methyl-4-oxo-3,4-dihydropyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carboxylate

There total 3 articles about ethyl 2-chloromethyl-9-(4'-chlorophenyl)-7-methyl-4-oxo-3,4-dihydropyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 79-04-9
chloroacetyl chloride

: 298206-19-6
3-amino-(4'-chlorophenyl)-5-ethoxycarbonyl-6-methylthieno[2,3-b]pyridine-2-carboxamide

: 868682-44-4
ethyl 2-chloromethyl-9-(4'-chlorophenyl)-7-methyl-4-oxo-3,4-dihydropyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carboxylate

Guidance literature:: for 3h; Heating;
DOI:10.1002/jhet.5570420606

Reference yield:

: 97651-28-0
ethyl 4-(4'-chlorophenyl)-3-cyano-6-methyl-1,2-dihydropyridine-5-carboxylate

: 868682-44-4
ethyl 2-chloromethyl-9-(4'-chlorophenyl)-7-methyl-4-oxo-3,4-dihydropyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / sodium acetate trihydrate / ethanol / 3 h / Heating

2: 93 percent / sodium ethoxide / ethanol / 0.08 h / Heating

3: 87 percent / 3 h / Heating

With sodium ethanolate; sodium acetate; In ethanol; 2: Thorpe-Ziegler cyclization;
DOI:10.1002/jhet.5570420606

Reference yield:

: 298206-17-4
(4-(4'-chlorophenyl)-3-cyano-5-ethoxycarbonyl-6-methyl)pyridin-2-ylthioacetamide

: 868682-44-4
ethyl 2-chloromethyl-9-(4'-chlorophenyl)-7-methyl-4-oxo-3,4-dihydropyrido[3',2':4,5]thieno[3,2-d]pyrimidine-8-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / sodium ethoxide / ethanol / 0.08 h / Heating

2: 87 percent / 3 h / Heating

With sodium ethanolate; In ethanol; 1: Thorpe-Ziegler cyclization;
DOI:10.1002/jhet.5570420606