1-ACETYL-4-METHYLPIPERAZINE HYDROCHLORIDE

Base Information

• Chemical Name: 1-ACETYL-4-METHYLPIPERAZINE HYDROCHLORIDE
• CAS No.: 60787-05-5
• Molecular Formula: C7H14N2O
• Molecular Weight: 142.201
• Hs Code.: 2933599090
• Mol file: 60787-05-5.mol

Synonyms:Piperazine,1-acetyl-4-methyl- (7CI,9CI);1-Acetyl-4-methylpiperazine;4-Acetyl-1-methylpiperazine;

Chemical Property of 1-ACETYL-4-METHYLPIPERAZINE HYDROCHLORIDE

Chemical Property:

• Melting Point: 280 °C (decomp)
• Boiling Point: 241.4 °C at 760 mmHg
• PKA: 6.84±0.10(Predicted)
• Flash Point: 99.9 °C
• PSA: 23.55000
• Density: 1.017 g/cm³
• LogP: -0.34390
• Storage Temp.: Desiccate at RT

Purity/Quality:

97% ^*data from raw suppliers

1-Acetyl-4-methylpiperazine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Acetyl-4-methylpiperazine Hydrochloride is used in the preparation of (acetyl)piperazinium iodide and pyrrolopyrazinium iodides as nicotinic agonists.

Technology Process of 1-ACETYL-4-METHYLPIPERAZINE HYDROCHLORIDE

There total 3 articles about 1-ACETYL-4-METHYLPIPERAZINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

1-methyl-piperazine (109-01-3) + N-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-5-(3,4-dimethoxybenzylidene)rhodanine (65562-18-7) → (Z)-2-Mercapto-1-(4-methyl-piperazin-1-yl)-3-phenyl-propenone + N-(1-β-D-glucopyranosyl)-4-methylpiperazine-1-carbothioamide + 1-(4-methylpiperazin-l-yl)ethan-1-one (60787-05-5)

Guidance literature:

In methanol; Ambient temperature;

DOI:10.1002/jps.2600700924

Reference yield:

4-acetyl-1-(4-hydroxyphenyl)-1-methylpiperazin-1-ium triflate → 1-(4-methylpiperazin-l-yl)ethan-1-one (60787-05-5) + phenol (108-95-2,27073-41-2)

Guidance literature:

With 1,3-dicyano-2,4,5,6-tetrakis(N,N-diphenylamino)-benzene; tert-butylammonium hexafluorophosphate(V); triethylamine; In N,N-dimethyl-formamide; for 12h; Overall yield = 54 percentChromat.; Inert atmosphere; Sealed tube; Irradiation; Electrolysis;

DOI:10.1002/anie.202107169

Reference yield:

N-acetyl-N'-(4-hydroxyphenyl)piperazine (67914-60-7,89929-31-7) → 1-(4-methylpiperazin-l-yl)ethan-1-one (60787-05-5) + phenol (108-95-2,27073-41-2)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane; diethyl ether / 0 - 20 °C / Inert atmosphere

2: 1,3-dicyano-2,4,5,6-tetrakis(N,N-diphenylamino)-benzene; tert-butylammonium hexafluorophosphate(V); triethylamine / N,N-dimethyl-formamide / 12 h / Inert atmosphere; Sealed tube; Irradiation; Electrolysis

With 1,3-dicyano-2,4,5,6-tetrakis(N,N-diphenylamino)-benzene; tert-butylammonium hexafluorophosphate(V); triethylamine; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/anie.202107169

upstream raw materials:

1-methyl-piperazine

N-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-5-(3,4-dimethoxybenzylidene)rhodanine

N-acetyl-N'-(4-hydroxyphenyl)piperazine

Downstream raw materials:

4-acetyl-1,1-dimethylpiperazinium iodide

2-<7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-ylidene>-1-(4-methyl-1-piperazinyl)ethanone 4-oxide