(3R,4R)-methyl 4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylate

Base Information

Chemical Name:(3R,4R)-methyl 4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylate
CAS No.:1173565-53-1
Molecular Formula:C₂₁H₂₃NO₅
Molecular Weight:369.417
Hs Code.:

Synonyms:(3R,4R)-methyl 4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylate

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Chemical Property of (3R,4R)-methyl 4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylate

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Technology Process of (3R,4R)-methyl 4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylate

There total 2 articles about (3R,4R)-methyl 4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1173565-51-9
(R)-1-ethyl 4-methyl 2-hydroxy-2-(4-methoxyphenyl)-3-((1-phenylethylamino)methyl)succinate

: 1173565-53-1
(3R,4R)-methyl 4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylate

Guidance literature:: With trifluoroacetic acid; In 1,4-dioxane; for 24h; Reflux;

Reference yield:

: 1173565-49-5
1-ethyl 4-methyl 2-hydroxy-2-(4-methoxyphenyl)-3-methylenesuccinate

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 1173565-53-1
(3R,4R)-methyl 4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylate

Guidance literature:: 1-ethyl 4-methyl 2-hydroxy-2-(4-methoxyphenyl)-3-methylenesuccinate; (R)-1-phenyl-ethyl-amine; In methanol;

With trifluoroacetic acid; In 1,4-dioxane; for 72h; Reflux;
DOI:10.1016/j.bmcl.2010.05.046

Reference yield: 83.0%

: 1173565-53-1
(3R,4R)-methyl 4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylate

: 1173565-56-4
(3S,4R)-4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylic acid

Guidance literature:: (3R,4R)-methyl 4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylate; With water; sodium hydroxide; In methanol; at 20 ℃; for 6h;

With hydrogenchloride; In water;