5,7-difluoro-2-(4-methoxymethoxy-3,5-dimethylphenyl)-3H-quinazolin-4-one

Base Information

Chemical Name:5,7-difluoro-2-(4-methoxymethoxy-3,5-dimethylphenyl)-3H-quinazolin-4-one
CAS No.:1253731-83-7
Molecular Formula:C₁₈H₁₆F₂N₂O₃
Molecular Weight:346.333
Hs Code.:

Synonyms:5,7-difluoro-2-(4-methoxymethoxy-3,5-dimethylphenyl)-3H-quinazolin-4-one

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Chemical Property of 5,7-difluoro-2-(4-methoxymethoxy-3,5-dimethylphenyl)-3H-quinazolin-4-one

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Technology Process of 5,7-difluoro-2-(4-methoxymethoxy-3,5-dimethylphenyl)-3H-quinazolin-4-one

There total 3 articles about 5,7-difluoro-2-(4-methoxymethoxy-3,5-dimethylphenyl)-3H-quinazolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 893428-66-5
2-amino-4,6-difluoro-benzamide

: 157028-15-4
4-(methoxymethoxy)-3,5-dimethylbenzaldehyde

: 1253731-83-7
5,7-difluoro-2-(4-methoxymethoxy-3,5-dimethylphenyl)-3H-quinazolin-4-one

Guidance literature:: With toluene-4-sulfonic acid; sodium hydrogensulfite; In N,N-dimethyl acetamide; at 120 ℃; for 16h; Inert atmosphere;

Reference yield:

: 126674-77-9
2-amino-4,6-difluorobenzoic acid

: 1253731-83-7
5,7-difluoro-2-(4-methoxymethoxy-3,5-dimethylphenyl)-3H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 1 h / 20 °C

1.2: 6 h / 20 °C

2.1: sodium hydrogen sulfate; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 16 h / 120 °C / Inert atmosphere

With sodium hydrogen sulfate; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; N,N-dimethyl acetamide;

Reference yield:

: 2233-18-3
4-hydroxy-3,5-dimethylbenzaldehyde

: 1253731-83-7
5,7-difluoro-2-(4-methoxymethoxy-3,5-dimethylphenyl)-3H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere

1.2: 16 h / 20 °C / Inert atmosphere

2.1: sodium hydrogen sulfate; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 16 h / 120 °C / Inert atmosphere

With sodium hydrogen sulfate; sodium hydride; toluene-4-sulfonic acid; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;