2,3-DIHYDRO-1H-INDOLE-3-CARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 2,3-DIHYDRO-1H-INDOLE-3-CARBOXYLIC ACID METHYL ESTER
• CAS No.: 528862-00-2
• Molecular Formula: C₁₅H₁₉NO₄
• Molecular Weight: 277.32
• Hs Code.: 2933990090
• Mol file: 528862-00-2.mol

Synonyms:1-(tert-Butoxycarbonyl)indoline-3-carboxylicacid methyl ester

Chemical Property of 2,3-DIHYDRO-1H-INDOLE-3-CARBOXYLIC ACID METHYL ESTER

Chemical Property:

• PSA: 55.84000
• LogP: 2.76330

Purity/Quality:

98% ^*data from raw suppliers

Methyl1-Boc-indoline-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-DIHYDRO-1H-INDOLE-3-CARBOXYLIC ACID METHYL ESTER

There total 4 articles about 2,3-DIHYDRO-1H-INDOLE-3-CARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl 1-tert-butoxycarbonyl-1H-indole-3-carboxylate (338760-26-2) → methyl 1-(tert-butoxycarbonyl)indoline-3-carboxylate (528862-00-2)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In methanol; ethyl acetate; for 72h; under 3102.97 Torr;

Reference yield:

3-methoxycarbonylindole (942-24-5) → methyl 1-(tert-butoxycarbonyl)indoline-3-carboxylate (528862-00-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / NaH / tetrahydrofuran

2: 68 percent / H₂ / 5 percent Pd/C / methanol; ethyl acetate / 120 h / 20 °C / 5688.63 Torr

With hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate;

DOI:10.1016/S0040-4020(02)01627-7

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → methyl 1-(tert-butoxycarbonyl)indoline-3-carboxylate (528862-00-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / NaH / tetrahydrofuran

2: 68 percent / H₂ / 5 percent Pd/C / methanol; ethyl acetate / 120 h / 20 °C / 5688.63 Torr

With hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate;

DOI:10.1016/S0040-4020(02)01627-7

upstream raw materials:

methyl 1-tert-butoxycarbonyl-1H-indole-3-carboxylate

3-methoxycarbonylindole

di-tert-butyl dicarbonate

Downstream raw materials:

methyl 1-formylindoline-3-carboxylate

indolin-3-yldiphenylmethanol

3-[(tert-butyldimethylsilyloxy)diphenylmethyl]indoline

3-[diphenyl(trimethylsilyloxy)]methyl-indoline

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