C₃₁H₂₈N₂O₂

Base Information

• Chemical Name: C₃₁H₂₈N₂O₂
• CAS No.: 1352035-40-5
• Molecular Formula: C₃₁H₂₈N₂O₂
• Molecular Weight: 460.576
• Mol file: 1352035-40-5.mol

Synonyms:C₃₁H₂₈N₂O₂

Chemical Property of C₃₁H₂₈N₂O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₁H₂₈N₂O₂

There total 7 articles about C₃₁H₂₈N₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-([1,1:3',1''-terphenyl]-5'-yl)-1-chloro-6,7-dimethoxyisoquinoline (1352036-18-0) + dimethyl amine (124-40-3) → C31H28N2O2 (1352035-40-5)

Guidance literature:

With lithium hexamethyldisilazane; chloro(2-di-t-butylphosphino-2',4',6'-tri-1-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]pd(II); In tetrahydrofuran; at 20 ℃; Inert atmosphere;

Reference yield:

5,6-dimethoxy-1-indanone (2107-69-9) → C31H28N2O2 (1352035-40-5)

Guidance literature:

Multi-step reaction with 7 steps

1.1: hydrogenchloride; n-Butyl nitrite / water; methanol / 2.5 h / 40 °C

2.1: sodium hydroxide; p-toluenesulfonyl chloride / water / 0.25 h / 50 - 80 °C

2.2: pH 3 - 4

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / Inert atmosphere

4.1: hydrogen bromide / diethyl ether / 2 h

5.1: potassium carbonate / palladium diacetate; XPhos / acetonitrile; water / 1.5 h / 100 °C

6.1: trichlorophosphate / 3 h / 110 °C

7.1: lithium hexamethyldisilazane / chloro(2-di-t-butylphosphino-2',4',6'-tri-1-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]pd(II) / tetrahydrofuran / 20 °C / Inert atmosphere

With hydrogenchloride; oxalyl dichloride; n-Butyl nitrite; hydrogen bromide; potassium carbonate; p-toluenesulfonyl chloride; sodium hydroxide; lithium hexamethyldisilazane; trichlorophosphate; chloro(2-di-t-butylphosphino-2',4',6'-tri-1-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]pd(II); palladium diacetate; N,N-dimethyl-formamide; XPhos; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetonitrile;

Reference yield:

2-(cyanomethyl)-4,5-dimethoxybenzoic acid (76254-26-7) → C31H28N2O2 (1352035-40-5)

Guidance literature:

Multi-step reaction with 5 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: hydrogen bromide / diethyl ether / 2 h

3: potassium carbonate / palladium diacetate; XPhos / acetonitrile; water / 1.5 h / 100 °C

4: trichlorophosphate / 3 h / 110 °C

5: lithium hexamethyldisilazane / chloro(2-di-t-butylphosphino-2',4',6'-tri-1-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]pd(II) / tetrahydrofuran / 20 °C / Inert atmosphere

With oxalyl dichloride; hydrogen bromide; potassium carbonate; lithium hexamethyldisilazane; trichlorophosphate; chloro(2-di-t-butylphosphino-2',4',6'-tri-1-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]pd(II); palladium diacetate; N,N-dimethyl-formamide; XPhos; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetonitrile;

upstream raw materials:

3-([1,1:3',1''-terphenyl]-5'-yl)-1-chloro-6,7-dimethoxyisoquinoline

dimethyl amine

5,6-dimethoxy-1-indanone

2-(cyanomethyl)-4,5-dimethoxybenzoic acid