(3-Aminopyridin-4-yl)methanol

Base Information

• Chemical Name: (3-Aminopyridin-4-yl)methanol
• CAS No.: 152398-05-5
• Molecular Formula: C6H8N2O
• Molecular Weight: 124.14
• Hs Code.: 29333990
• European Community (EC) Number: 826-606-2
• ChEMBL ID: CHEMBL4592707
• DSSTox Substance ID: DTXSID20565949
• Nikkaji Number: J1.830.198I
• Wikidata: Q72437889
• Mol file: 152398-05-5.mol

Synonyms:152398-05-5;(3-Aminopyridin-4-yl)methanol;(3-Amino-pyridin-4-yl)-methanol;3-AMINOPYRIDINE-4-METHANOL;3-Amino-4-hydroxymethylpyridine;MFCD06658330;4-PYRIDINEMETHANOL, 3-AMINO-;(3-amino-4-pyridinyl)methanol;(3-Amino-4-pyridyl)methanol;SCHEMBL1646754;CHEMBL4592707;DTXSID20565949;(3-Aminopyridine-4-yl)-methanol;VXHFPFMVXWCZLH-UHFFFAOYSA-N;AMY41940;AKOS005073635;AB25787;NC-0715;AC-28208;SY007348;CS-0157313;(3-Amino-pyridin-4-yl)-methanol, AldrichCPR;EN300-94716;F13531;A809303;J-501129;(3-amino-4-pyridyl)methanol;3-Aminopyridine-4-methanol;F1907-9474;Z1201623606

Chemical Property of (3-Aminopyridin-4-yl)methanol

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 118.7-118.9°C
• Refractive Index: 1.628
• Boiling Point: 366.554 °C at 760 mmHg
• PKA: 13.31±0.10(Predicted)
• Flash Point: 175.486 °C
• PSA: 59.14000
• Density: 1.257 g/cm³
• LogP: 0.73730
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 124.063662883
• Heavy Atom Count: 9
• Complexity: 87.1

Purity/Quality:

97% ^*data from raw suppliers

(3-Amino-pyridin-4-yl)-methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=CC(=C1CO)N

Technology Process of (3-Aminopyridin-4-yl)methanol

There total 5 articles about (3-Aminopyridin-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl 3-aminopyridine-4-carboxylate (14208-83-4) → (3-amino-pyridin-4-yl)methanol (152398-05-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 5 ℃; for 2h;

Reference yield: 72.0%

3-Aminopyridine-4-carboxylic acid (7579-20-6) → (3-amino-pyridin-4-yl)methanol (152398-05-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 48h;

Reference yield:

3,4-pyridinedicarboximide (4664-01-1) + MeOH (NH3) → (3-amino-pyridin-4-yl)methanol (152398-05-5)

Guidance literature:

With bromine; In tetrahydrofuran; methanol; sodium hydroxide; water; acetic acid;

upstream raw materials:

ethyl 3-aminopyridine-4-carboxylate

3,4-pyridinedicarboximide

3-Aminopyridine-4-carboxylic acid

Downstream raw materials:

3-amino-pyridine-4-carbaldehyde

N-[4-(hydroxymethyl)-3-pyridinyl]-2-[(phenylmethyl)oxy]-5-(4-pyridinyl)benzamide

4-((4-nitronaphthalen-1-yloxy)methyl)pyridin-3-amine

1-(4-((3-aminopyridin-4-yl)methoxy)naphthalen-1-yl)-3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)urea